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        Maternal Late-Pregnancy Serum Unmetabolized Folic Acid Concentrations Are Not Associated with Infant Allergic Disease: A Prospective Cohort Study

        The increase in childhood allergic disease in recent decades has coincided with increased folic acid intakes during pregnancy. Circulating unmetabolized folic acid (UMFA) has been proposed as a biomarker of excessive folic acid intake. We aimed to determine if late-pregnancy serum UMFA and total folate concentrations were associated with allergic disease risk in the offspring at 1 y of age in a population at high risk of allergy. ...

        Research

        Therapeutic targeting of the leukaemia microenvironment

        In recent decades, the conduct of uniform prospective clinical trials has led to improved remission rates and survival for patients with acute myeloid leukaemia and acute lymphoblastic leukaemia. However, high-risk patients continue to have inferior outcomes, where chemoresistance and relapse are common due to the survival mechanisms utilised by leukaemic cells. ...

        Research

        Assessment of different techniques for the administration of inhaled salbutamol in children breathing spontaneously via tracheal tubes, supraglottic airway devices, and tracheostomies

        Perioperative respiratory adverse events account for a third of all perioperative cardiac arrests, with bronchospasm and laryngospasm being most common. Standard treatment for bronchospasm is administration of inhaled salbutamol, via pressurized metered dose inhaler. There is little evidence on the best method of attaching the pressurized metered dose inhaler to the artificial airway during general anesthesia. The aim of this study is to investigate the best method to deliver aerosolized salbutamol via pressurized metered dose inhaler to the lungs of an anesthetized child. ...

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        Clinical Ecology-Transforming 21st-Century Medicine with Planetary Health in Mind

        The grand, interconnected challenges of our time demands that all of medicine be viewed from an ecological perspective ...

        Research

        Prebiotics: mechanisms and preventive effects in allergy

        In this review, we describe both the mechanisms and the therapeutic evidence from preclinical and clinical studies exploring the role of prebiotics in allergy prevention ...

        Research

        Outcome of Infants Younger Than 1 Year With Acute Lymphoblastic Leukemia Treated With the Interfant-06 Protocol: Results From an International Phase III Randomized Study

        Early intensification with postinduction myeloid-type chemotherapy courses did not significantly improve outcome for infant acute lymphoblastic leukemia ...

        Research

        Preterm birth: Born too soon for the developing airway epithelium

        This review examines the consequences of preterm birth on the airway epithelium and explores the clinical relevance of currently available models ...

        Research

        Impact of Childhood Pneumococcal Conjugate Vaccine on Nonnotified Clinically Suspected Invasive Pneumococcal Disease in Australia

        This study provides a quantitative estimate of the total burden of invasive pneumococcal disease preventable by vaccination programs in Australia ...

        Research

        Poverty, Parental Mental Health and Child/Adolescent Mental Disorders: Findings from a National Australian Survey

        The purpose of this study is to examine the association between poverty and child mental disorders ...

        Research

        Risk factors for symptomatic venous thromboembolism during therapy for childhood acute lymphoblastic leukemia

        We found two known risk factors in a large cohort of children treated for ALL and identified other factors associated with venous thromboembolism ...

        Research

        Impact of Micronutrient Status during Pregnancy on Early Nutrition Programming

        Globally and even in high-income countries where a balanced diet is generally accessible, an inadequate maternal micronutrient status is common ...

        Research

        An Australian Consensus on Infant Feeding Guidelines to Prevent Food Allergy: Outcomes From the Australian Infant Feeding Summit

        Infant feeding in the first postnatal year of life has an important role in an infant's risk of developing food allergy ...

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