In the Saline Hypertonic in Preschoolers (SHIP) study, inhaled 7% hypertonic saline improved the lung clearance index in children aged 3-6 years with cystic fibrosis, but it remained unclear whether improvement is also seen in structural lung disease. We aimed to assess the effect of inhaled hypertonic saline on chest CT imaging in children aged 3-6 years with cystic fibrosis. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• March 2022

Structural and functional defects within the lungs of children with cystic fibrosis (CF) are detectable soon after birth and progress throughout preschool years often without overt clinical signs or symptoms. By school age, most children have structural changes such as bronchiectasis or gas trapping/hypoperfusion and lung function abnormalities that persist into later life. Despite improved survival, gains in forced expiratory volume in one second (FEV1) achieved across successive birth cohorts during childhood have plateaued, and rates of FEV1 decline in adolescence and adulthood have not slowed. This suggests that interventions aimed at preventing lung disease should be targeted to mild disease and commence in early life. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• April 2021

Individuals with cystic fibrosis (CF) are given antimicrobials as prophylaxis against bacterial lung infection, which contributes to the growing emergence of multidrug resistant (MDR) pathogens isolated. Pathogens such as Pseudomonas aeruginosa that are commonly isolated from individuals with CF are armed with an arsenal of protective and virulence mechanisms, complicating eradication and treatment strategies. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• January 2021

These results show that a word gap related to maternal education is not apparent up to twelve months of age ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• February 2020

This study examined stakeholders' perceptions regarding the acceptability, usability, and dissemination of the Australian 24-Hour Movement Guidelines ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• January 2020

Infants with Tuberous sclerosis complex demonstrated reduced interhemispheric alpha phase coherence compared to controls at 12 months of age ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• December 2019

We report on the prevalence and trends of hypospadias which indicate that the prevalence of hypospadias continues to increase internationally ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• October 2019

Efforts to eliminate ARF and RHD in Australia over the past decade have so far been unsuccessful, but this can change ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• September 2019

Here we review the metabolic effects of exposure to ultraviolet radiation, focusing on the effects of phototherapies ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• August 2019

Most parents are supportive of vaccination. Sociodemographic factors may contribute more to the risk of incomplete vaccination than attitudes or beliefs. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• April 2019

The findings indicated that in spite of continued promotion of the AIFG over the past ten years achieving the around six months guideline is challenging ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• March 2019

The rise of sedimentary ancient DNA (sedaDNA) studies has opened new possibilities for studying past environments. This groundbreaking area of genomics uses sediments to identify organisms, even in cases where macroscopic remains no longer exist. Managing this substrate in Indigenous Australian contexts, however, requires special considerations. Sediments and soils are often considered as waste by-products during archaeological and paleontological excavations and are not typically regulated by the same ethics guidelines utilised in mainstream 'western' research paradigms. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• July 2023