Many children with intellectual disability live with medical comorbidities. This study examined the impacts of comorbidities on quality of life (QOL) of children with intellectual disabilities and whether impacts varied with caregiver perceptions that medical needs had been met. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• April 2021

The introduction of a formal medical team to Hospital in the Home (HiTH) demonstrated a positive clinical impact on Parenteral Antimicrobial Therapy (OPAT) patients' outcomes. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• August 2017

Gastrostomy placement was associated with improvement in BMI in females with Rett syndrome, but its long-term impact on individuals and their families is unclear ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• September 2018

Parent observations provide an initial framework for understanding quality of life in autism spectrum disorder ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• January 2019

We investigated parental observations to identify QOL domains in children with Down Syndrome and determined whether domains differed between children and teens. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• February 2017

Findings show that indicators of a poor intrauterine environment are associated with an elevated risk of ID, while for ASD, and particularly ASD without ID,... ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• January 2013

Glioblastoma in adults, and medulloblastoma and pineoblastoma that mainly affect children, are aggressive brain tumors. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• March 2018

From 1990 to 2005, there was an increase in prevalence of parents with a prior history of mental health disorders in WA. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• May 2013

This paper examines the use of a new antibiotic to treat diarrhoea cause by Cryptosporidium infection in Australian Indigenous children. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• June 2014

Recurrences frequently occur following surgical removal of primary tumors. In many cancers, adjuvant therapies have limited efficacy. Surgery provides access to the tumor microenvironment, creating an opportunity for local therapy, in particular immunotherapy, which can induce local and systemic anti-cancer effects. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• July 2023

Medulloblastoma (MB) consists of four core molecular subgroups with distinct clinical features and prognoses. Treatment consists of surgery, followed by radiotherapy and cytotoxic chemotherapy. Despite this intensive approach, outcome remains dismal for patients with certain subtypes of MB, namely, MYC-amplified Group 3 and TP53-mutated SHH. Using high-throughput assays, six human MB cell lines were screened against a library of 3208 unique compounds. We identified 45 effective compounds from the screen and found that cell cycle checkpoint kinase (CHK1/2) inhibition synergistically enhanced the cytotoxic activity of clinically used chemotherapeutics cyclophosphamide, cisplatin, and gemcitabine. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• January 2021

Following a relative absence in winter 2020, a large resurgence of respiratory syncytial virus (RSV) detections occurred during the 2020/2021 summer in Western Australia. This seasonal shift was linked to SARS-CoV-2 public health measures. We examine the epidemiology and RSV testing of respiratory-coded admissions, and compare clinical phenotype of RSV-positive admissions between 2019 and 2020. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• March 2022