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        Common variants in the HLA-DRB1-HLA-DQA1 HLA class II region are associated with susceptibility to visceral leishmaniasis

        A conditional analysis provided evidence for multiple associations within the HLA-DRB1-HLA-DQA1 region,and a model in which risk differed between three... ...

        Research

        The effects of in utero vitamin D deficiency on airway smooth muscle mass and lung function

        In this study, we aimed to uncover the molecular mechanisms contributing to altered lung structure and function. ...

        Research

        Bioenteric Intragastric Balloon

        Liz Tim Davis Jones EA TW MBBS FRACP PhD MBBS DCH FRACP MD Head, Chronic & Severe Diseases Research Focus Area; Clinical Lead, Diabetes and Obesity Research Co-head, Diabetes and Obesity Research Head, Chronic & Severe Diseases Research Focus Area; ...

        Research

        Maternal HIV infection alters antimicrobial immunity in exposed and uninfected infants

        Implementation of lifelong ART of all HIV-infected women has the potential to improve maternal determinants of protective immunity in the young infant ...

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        Role of maternal mental health disorders on stillbirth and infant mortality risk: a protocol for a systematic review and meta-analysis

        We plan to examine whether prenatal maternal mental health disorders impact the risk of stillbirth and infant mortality ...

        Research

        Molecular Epidemiology of Noninvasive and Invasive Group A Streptococcal Infections in Cape Town

        There is low coverage of the multivalent M protein vaccine in our setting, emphasizing the need to reformulate the vaccine to improve coverage ...

        Research

        A broad autism phenotype expressed in facial morphology

        These data provide the first evidence for a broad autism phenotype expressed in a physical characteristic ...

        Research

        Exploiting the reactive oxygen species imbalance in high-risk paediatric acute lymphoblastic leukaemia through auranofin

        The prognosis for high-risk childhood acute leukaemias remains dismal and established treatment protocols often cause long-term side effects in survivors. This study aims to identify more effective and safer therapeutics for these patients. ...

        Research

        Birth seasonality and risk of autism spectrum disorder

        In the first multinational study of birth seasonality of autism spectrum disorder, there was evidence supporting the presence of seasonal trends in Finland and Sweden ...

        Research

        Changing Prevalence of Lower Airway Infections in Young Children with Cystic Fibrosis

        Aspergillus species and P. aeruginosa are commonly present in the lower airways from infancy ...

        Research

        HLA-DR Class II expression on myeloid and lymphoid cells in relation to HLA-DRB1 as a genetic risk factor for visceral leishmaniasis

        To understand how HLA-DR contributes to disease pathogenesis, we examined expression at the protein level in circulating myeloid and lymphoid cells of VL patients ...

        Research

        Use of a primary epithelial cell screening tool to investigate phage therapy in cystic fibrosis

        This study demonstrates the feasibility of utilizing pre-clinical in vitro culture models to screen therapeutic candidates ...

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