Cystic fibrosis (CF) lung disease commences early in the disease progression and is the most common cause of mortality. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• June 2013

The present study investigated whether lung function measured by forced oscillation technique would be impaired in the presence of infection,... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• September 2015

Children with medulloblastoma and ependymoma are treated with a multidisciplinary approach that incorporates surgery, radiotherapy, and chemotherapy; however, overall survival rates for patients with high-risk disease remain unsatisfactory. Data indicate that plant-derived cannabinoids are effective against adult glioblastoma; however, preclinical evidence supporting their use in pediatric brain cancers is lacking. Here we investigated the potential role for Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) in medulloblastoma and ependymoma. Dose-dependent cytotoxicity of medulloblastoma and ependymoma cells was induced by THC and CBD in vitro, and a synergistic reduction in viability was observed when both drugs were combined. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• January 2021

National Trachoma Surveillance and Reporting Unit to collate, analyse and report trachoma prevalence data and document trachoma control strategies in Australia ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• June 2016

A biologically active vaccine may produce a low measured vaccine efficacy under a range of epidemiological, vaccine-related and logistical conditions ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• May 2018

These baseline data are essential to assess the safety and effectiveness of influenza and pertussis vaccinations in pregnant women from the NT ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• January 2019

Fetal androgens influence fetal growth as well as postnatal neurocognitive ability. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2010
• March 2010

Direct and persistent vicarious racial discrimination are detrimental to the physical and mental health of Indigenous children in Australia ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• July 2017

Impaired interferon response and allergic sensitization may contribute to virus-induced wheeze and asthma development in young children. Plasmacytoid dendritic cells play a key role in antiviral immunity as critical producers of type I interferons.  ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• December 2023

Respiratory viruses significantly impact global morbidity and mortality, causing more disease in humans than any other infectious agent. Beyond pathogens, various viruses and bacteria colonize the respiratory tract without causing disease, potentially influencing respiratory diseases’ pathogenesis. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• June 2024

Upper and lower airways are conserved in their transcriptional composition, and variations associated with disease are present in both nasal and tracheal epithelium ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• June 2020

We demonstrate that NOTCH3 is a regulator of MUC5AC production ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• April 2020