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        Novel therapeutics approaches for infants with high-risk infant acute lymphoblastic leukaemia

        Rishi Sury Laurence Sébastien Kotecha Cheung Malinge RS LC SM MB ChB (Hons) MRCPCH FRACP PhD BPharm (Hons) MBA PhD PhD Co-Head, Leukaemia Translational Research Co-Head, Leukaemia Translational Research Laboratory Head, Translational Genomics in ...

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        PLAYCE PAWS: The health and developmental benefits of companion animals for young children

        Hayley Liz Steve Christian Wenden Zubrick HC LW SR BSc (1st Class Hons), PhD W.Aust. BHlthSc MPH FASSA, FAAMHS, MSc AM PhD Program Head, Healthy Behaviours and Environments; National Heart Foundation Future Leader Fellow Research Assistant/Data ...

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        The Sun Safe app: a new online tool to promote safe sun behaviours by teenagers

        Gail Prue Shelley Alvares Hart Gorman GA PH S PhD BSc (Hons) MSc PhD BSc (Hons) PhD Senior Research Fellow Head, Inflammation Honorary Research Associate 08 6319 1698 gail.alvares@telethonkids.org.au prue.hart@telethonkids.org.au shelley.gorman@ ...

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        WA Department of Health Merit Awards - Project - Improving Aboriginal health disparities: the influence of education, child protection and justice systems over time and across generations

        Francis Sarah Mitrou Johnson FG SJ BEc BA, PostGradDip; PhD Program Head, Population Health, and Team Head, Human Development and Community Wellbeing Senior Research Fellow 08 6319 1499 francis.mitrou@telethonkids.org.au Sarah.Johnson@ ...

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        Early Childhood Development

        Every child deserves the best possible start in life. Evidence demonstrates the period from pre-birth to three years is a vital period of development. It lays the foundations for a child’s future and has life-long impacts on health, education, job opportunities, social inclusion and wellbeing. ...

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        ONC201 in Combination with Paxalisib for the Treatment of H3K27-Altered Diffuse Midline Glioma

        Diffuse midline gliomas (DMG), including diffuse intrinsic pontine gliomas (DIPG), are the most lethal of childhood cancers. Palliative radiotherapy is the only established treatment, with median patient survival of 9 to 11 months. ONC201 is a DRD2 antagonist and ClpP agonist that has shown preclinical and emerging clinical efficacy in DMG.  ...

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        Change in health outcomes for First Nations children with chronic wet cough: rationale and study protocol for a multi-centre implementation science study

        In children, chronic wet cough may be a sign of underlying lung disease, including protracted bacterial bronchitis (PBB) and bronchiectasis. Chronic (> 4 weeks in duration) wet cough (without indicators pointing to alternative causes) that responds to antibiotic treatment is diagnostic of PBB. Timely recognition and management of PBB can prevent disease progression to irreversible bronchiectasis with lifelong consequences. However, detection and management require timely health-seeking by carers and effective management by clinicians. ...

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        Continuity of temperament subgroup classifications from infancy to toddlerhood in the context of early autism traits

        Our previous cross-sectional investigation (Chetcuti et al., 2020) showed that infants with autism traits could be divided into distinct subgroups based on temperament. This longitudinal study builds on this existing work by exploring the continuity of temperament subgroup classifications and their associations with behavioral/clinical phenotypic features from infancy to toddlerhood. ...

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        Normative data for multiple breath washout outcomes in school-aged Caucasian children

        The multiple breath nitrogen washout (N2MBW) technique is increasingly used to assess the degree of ventilation inhomogeneity in school-aged children with lung disease. However, reference values for healthy children are currently not available. ...

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        The prevalence of and potential risk factors for Developmental Language Disorder at 10 years in the Raine Study

        This study sought to determine the prevalence of Developmental Language Disorder (DLD) in Australian school-aged children and associated potential risk factors for DLD at 10 years. ...

        Research

        AI-Driven Cell Tracking to Enable High-Throughput Drug Screening Targeting Airway Epithelial Repair for Children with Asthma

        The airway epithelium of children with asthma is characterized by aberrant repair that may be therapeutically modifiable. The development of epithelial-targeting therapeutics that enhance airway repair could provide a novel treatment avenue for childhood asthma. ...

        Research

        Constitutive Activation of RAS/MAPK Pathway Cooperates with Trisomy 21 and Is Therapeutically Exploitable in Down Syndrome B-cell Leukemia

        Children with Down syndrome (constitutive trisomy 21) that develop acute lymphoblastic leukemia (DS-ALL) have a 3-fold increased likelihood of treatment-related mortality coupled with a higher cumulative incidence of relapse, compared with other children with B-cell acute lymphoblastic leukemia (B-ALL). ...

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