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        Increased Use of Adrenaline in the Management of Childhood Anaphylaxis Over the Last Decade

        There was a significant improvement in the management of anaphylaxis after the introduction of intensified physician training programs ...

        Research

        Burkholderia pseudomallei evades Nramp1 (Slc11a1)- and NADPH oxidase-mediated killing in macrophages and exhibits Nramp1-dependent virulence gene expression

        Here we show that transfected macrophages stably expressing wild-type Nramp1 (Nramp1+) control the net replication of B. thailandensis, but not B. pseudomallei. ...

        Research

        Trends in alcohol-related injury admissions in adolescents in Western Australia and England: Population-based cohort study

        More needs to be done to address alcohol-related harm, and on-going monitoring is required to assess the effectiveness of strategies. ...

        Research

        The Microbiome and Mental Health: Looking Back, Moving Forward with Lessons from Allergic Diseases

        The microbiome is intimately connected to diet, nutrition, and other lifestyle variables ...

        Research

        Physician training programs significantly improve diagnosis in cases coded as anaphylaxis over time: A major factor compounding time-trend data?

        We conducted an investigation of all cases coded as anaphylaxis presenting to the main tertiary PED in Perth, Australia, where all coding is performed by staff. ...

        Research

        Production of IgG antibodies to pneumococcal polysaccharides is associated with expansion of ICOS+ circulating memory T follicular-helper cells which is impaired by HIV infection

        Dysfunction of T follicular-helper cells is a possible cause of impaired germinal centre and IgG antibody responses in individuals with HIV ...

        Research

        Insights into the possible role of IFNG and IFNGR1 in Kala-azar and Post Kala-azar Dermal Leishmaniasis in Sudanese patients

        Uniformly low expression of IFN and IFNGR1 in PKDL skin biopsies could explain parasite persistence ...

        Research

        Early mortality and primary causes of death in mothers of children with intellectual disability or Autism spectrum disorder

        Mothers of children with intellectual disability or autism spectrum disorder (ASD) have poorer health than other mothers. ...

        Research

        Disease prevention in the age of convergence - The need for a wider, long ranging and collaborative vision

        Our global health crisis and the pandemic of noncommunicable diseases (NCDs) is clearly rooted in complex modern societal and environmental changes, many of... ...

        Research

        Effect of Maternal Influenza Vaccination on Hospitalization for Respiratory Infections in Newborns: A Retrospective Cohort Study

        Maternal influenza vaccination was associated with a reduction in the incidence of hospital admission for acute respiratory illness among infants <6 months old ...

        Research

        Epidemiology of seasonal influenza infection in pregnant women and its impact on birth outcomes

        Results from this linked population study suggests that there are differences in maternal infection by virus type and support the provision of seasonal vaccines ...

        Research

        Wound healing genes and susceptibility to cutaneous leishmaniasis in Brazil

        Here we examined single nucleotide polymorphisms (SNPs) in these genes as risk factors for cutaneous (CL) and mucosal leishmaniasis (ML), and leishmaniasis... ...

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