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        Normative data for multiple breath washout outcomes in school-aged Caucasian children

        The multiple breath nitrogen washout (N2MBW) technique is increasingly used to assess the degree of ventilation inhomogeneity in school-aged children with lung disease. However, reference values for healthy children are currently not available. ...

        Research

        Change in health outcomes for First Nations children with chronic wet cough: rationale and study protocol for a multi-centre implementation science study

        In children, chronic wet cough may be a sign of underlying lung disease, including protracted bacterial bronchitis (PBB) and bronchiectasis. Chronic (> 4 weeks in duration) wet cough (without indicators pointing to alternative causes) that responds to antibiotic treatment is diagnostic of PBB. Timely recognition and management of PBB can prevent disease progression to irreversible bronchiectasis with lifelong consequences. However, detection and management require timely health-seeking by carers and effective management by clinicians. ...

        Research

        Australian hospital paediatricians and nurses’ perspectives and practices for influenza vaccine delivery in children with medical comorbidities

        Influenza vaccination of children with medical comorbidities is critical due their increased risks for severe influenza disease. In Australia, hospitals are an avenue for influenza vaccine delivery to children with comorbidities but are not always effectively utilised. Qualitative enquiry sought to ascertainment the barriers and enablers for influenza vaccination recommendation, delivery, and recording of these children at Australian hospitals. ...

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        Polymorphism in a lincRNA Associates with a Doubled Risk of Pneumococcal Bacteremia in Kenyan Children

        Identified an association between polymorphisms in a long intergenic non-coding RNA (lincRNA) gene (AC011288.2) and pneumococcal bacteremia ...

        Research

        Biodiversity, the Human Microbiome and Mental Health: Moving toward a New Clinical Ecology for the 21st Century?

        With a focus on the microbiome as it pertains to mental health, we define environmental “grey space” and emphasize a new frontier involving bio-eco-psychological medicine ...

        Research

        The effectiveness of influenza vaccination in preventing hospitalisation in children in Western Australia

        This study aimed to determine the vaccine effectiveness of the southern hemisphere trivalent inactivated influenza vaccine (TIV) in preventing... ...

        Research

        Onset of maternal psychiatric disorders after the birth of a child with autism spectrum disorder: A retrospective cohort study

        Mothers of a child with autism spectrum disorder have more psychiatric disorders after the birth of their child. ...

        Research

        Optimization is required when using linked hospital and laboratory data to investigate respiratory infections

        Despite a recommendation for microbiological testing, only 45% of children hospitalized for respiratory infections in our previous data linkage study linked... ...

        Research

        Germ-line and somatic DICER1 mutations in pineoblastoma

        This study suggests that germ-line DICER1 mutations make a clinically significant contribution to PinB, establishing DICER1 as an important susceptibility... ...

        Research

        EAACI food allergy and anaphylaxis guidelines: diagnosis and management of food allergy

        Food allergy can have significant effects on morbidity and quality of life and can be costly in terms of medical visits and treatments. ...

        Research

        Epigenome-wide association study reveals longitudinally stable DNA methylation differences in CD4+ T cells from children with IgE-mediated food allergy

        Food allergy is mediated by a combination of genetic and environmental risk factors, potentially mediated by epigenetic mechanisms. ...

        Research

        The correlation between reading and mathematics ability at age twelve has a substantial genetic component

        Dissecting how genetic and environmental influences impact on learning is helpful for maximizing numeracy and literacy. ...

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