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        Early respiratory viral infections in infants with cystic fibrosis

        Early viral infections were associated with greater neutrophilic inflammation and bacterial pathogens ...

        Research

        Accumulation mode particles and LPS exposure induce TLR-4 dependent and independent inflammatory responses in the lung

        We aimed to delineate the effects of LPS and AMP on airway inflammation, and potential contribution to airway disease by measuring airway inflammatory responses ...

        Research

        Conditionally reprogrammed primary airway epithelial cells maintain morphology, lineage and disease specific functional characteristics

        Here, we show that conditionally reprogrammed airway epithelial cells (CRAECs) can be established from both healthy and diseased phenotypes. ...

        Research

        Transcription factor p63 regulates key genes and wound repair in human airway epithelial Basal cells

        The airway epithelium in asthma displays altered repair and incomplete barrier formation. ...

        Research

        Suppression of adrenomedullin contributes to vascular leakage and altered epithelial repair during asthma

        The anti-inflammatory peptide, adrenomedullin (AM), and its cognate receptor are expressed in lung tissue, but its pathophysiological significance in airway... ...

        Research

        The airway epithelium is a direct source of matrix degrading enzymes in bronchiolitis obliterans syndrome

        Long-term survival after lung transplantation is hindered by the development of bronchiolitis obliterans syndrome (BOS). ...

        Research

        STEPS - Equitable Approach to Early Self-Regulation Promotion

        Amy Helen Jenny Finlay-Jones Milroy Downs AFJ HM JA BPsych(Hons), MPsych(Clinical), MHealthEcon, PhD (Clin Psych) MBBS; FRANZCP; CATCAP BApplSci (physio) MSc PhD Head, Early Neurodevelopment & Mental Health; Healthway WA Senior Research Fellow ...

        Research

        A Review of Self-Compassion as an Active Ingredient in the Prevention and Treatment of Anxiety and Depression in Young People

        Previous meta-analyses have found higher self-compassion is associated with lower anxiety and depression. The aim of this study was to investigate the efficacy of self-compassion as an active ingredient in the treatment and prevention of anxiety and depression in youth. This was conducted through (i) a systematic review of the literature and (ii) qualitative consultation with young people and researchers in self-compassion. ...

        Research

        An in silico pipeline to filter the Toxoplasma gondii proteome for proteins that could traffic to the host cell nucleus and influence host cell epigenetic regulation

        To identify genes with putative epigenetic functions, we developed an in silico pipeline to interrogate the T. gondii proteome of 8313 proteins ...

        Research

        DEFEND CF: Biomarkers to define the treatment end-point for pulmonary exacerbations in cystic fibrosis

        Stephen Graham Stick Hall SM GL MB BChir PhD MRCP FRACP BAppSci PhD CRFS FANZSRS FThorSoc FERS Head, P4 Respiratory Health for Kids Honorary Research Associate Head, P4 Respiratory Health for Kids Honorary Research Associate Areas for research ...

        Research

        The Nutritional Quality of Kids’ Menus from Cafés and Restaurants: An Australian Cross‐Sectional Study

        Australian families increasingly rely on eating foods from outside the home, which in-creases intake of energy‐dense nutrient‐poor foods. ‘Kids’ Menus’ are designed to appeal to families and typically lack healthy options. However, the nutritional quality of Kids’ Menus from cafes and full‐service restaurants (as opposed to fast‐food outlets) has not been investigated in Australia. The aim of this study was to evaluate the nutritional quality of Kids’ Menus in restaurants and cafés in metropolitan Perth, Western Australia. ...

        Research

        Changes in airway inflammation with pseudomonas eradication in early cystic fibrosis

        Neutrophil elastase is a significant risk factor for structural lung disease in cystic fibrosis, and Pseudomonas aeruginosa airway infection is linked with neutrophilic inflammation and substantial respiratory morbidity. We aimed to evaluate how neutrophil elastase (NE) activity changes after P. aeruginosa eradication and influences early disease outcomes. We assessed participants in the AREST CF cohort between 2000 and 2018 who had P. aeruginosa cultured from their routine annual bronchoalveolar lavage (BAL) fluid and who underwent eradication treatment and a post eradication BAL. Factors associated with persistent P. aeruginosa infection, persistent neutrophilic inflammation following eradication and worse structural lung disease one year post-eradication were evaluated. ...

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