A range of safe and effective vaccines against SARS CoV 2 are needed to address the COVID 19 pandemic. We aimed to assess the safety and efficacy of the COVID-19 vaccine SCB-2019. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• January 2022

To assess the immunogenicity and safety of a 2009 influenza A(H1N1) vaccine in children. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2010
• January 2010

This study evaluated GSK's combined DTPa-IPV vaccine (Infanrix-IPV) given as a fifth consecutive acellular pertussis booster dose in conjunction... ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2006
• August 2006

There is intense interest in the interaction between microbial compounds and allergy. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2006
• May 2006

The minimum number of doses of pneumococcal conjugate vaccine required for protection is not known. We studied the immunogenicity of a reduced schedule in... ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2006
• April 2006

Children with Down syndrome (DS) are at increased risk of developing haematological malignancies, in particular acute megakaryoblastic leukaemia and acute lymphoblastic leukaemia. The microenvironment established by abnormal haematopoiesis driven by trisomy 21 is compounded by additional genetic and epigenetic changes that can drive leukaemogenesis in patients with DS. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• July 2024

Pediatric acute lymphoblastic leukemia (ALL) therapy is accompanied by treatment-related toxicities (TRTs) and impaired quality of life. In Australia and New Zealand, children with ALL are treated with either Children's Oncology Group (COG) or international Berlin-Frankfurt-Munster (iBFM) Study Group-based therapy. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• September 2022

Streptococcus pyogenes, also known as group A streptococcus (StrepA), is a bacterium that causes a range of human diseases, including pharyngitis, impetigo, invasive infections, and post-infection immune sequelae such as rheumatic fever and rheumatic heart disease. StrepA infections cause some of the highest burden of disease and death in mostly young populations in low-resource settings. Despite decades of effort, there is still no licensed StrepA vaccine, which if developed, could be a cost-effective way to reduce the incidence of disease.  ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• December 2023

KMT2A-rearranged infant acute lymphoblastic leukemia (ALL) represents the most refractory type of childhood leukemia. To uncover the molecular heterogeneity of this disease, we perform RNA sequencing, methylation array analysis, whole exome and targeted deep sequencing on 84 infants with KMT2A-rearranged leukemia. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• August 2022

The heart failure epidemic is growing and its prevention, in order to reduce associated hospital readmission rates and its clinical and economic burden, is a key issue in modern cardiovascular medicine. The present consensus document aims to provide practical evidence-based information to support the implementation of effective preventive measures. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• February 2022

Research and research funding must be independent of the tobacco industry, which continues to cause so much suffering ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• December 2018

Sepsis is the leading killer of children worldwide, but this is not reflected in estimates of global mortality. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• January 2015