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        Standardization of Epidemiological Surveillance of Invasive Group A Streptococcal Infections

        Invasive group A streptococcal (Strep A) infections occur when Streptococcus pyogenes, also known as beta-hemolytic group A Streptococcus, invades a normally sterile site in the body. This article provides guidelines for establishing surveillance for invasive Strep A infections. The primary objective of invasive Strep A surveillance is to monitor trends in rates of infection and determine the demographic and clinical characteristics of patients with laboratory-confirmed invasive Strep A infection, the age- and sex-specific incidence in the population of a defined geographic area, trends in risk factors, and the mortality rates and rates of nonfatal sequelae caused by invasive Strep A infections. ...

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        Australian Strep A Vaccine Initiative (ASAVI)

        Jonathan Glenn Katharine Carapetis AM Pearson Noonan JR G KN AM MBBS FRACP FAFPHM PhD FAHMS BA (Education) PhD Candidate MBBS (Hons) MSc Executive Director; Head, Strep A Translation; Co-Founder of REACH Director of First Nations Strategy and ...

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        Evaluating the use and effectiveness of passive immunization in reducing RSV-associated morbidity in high risk infants

        Hannah Tom Moore Snelling HC T OAM BSc (Hons) GradDipClinEpi PhD BMBS DTMH GDipClinEpid PhD FRACP Program Head, Infection and Vaccines Head, Infectious Disease Implementation Research 08 6319 1427 08 6319 1817 Hannah.moore@telethonkids.org.au ...

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        Exploring associations between life course geo-social exposures and rheumatic heart disease in Great Britain

        Jonathan Judy Carapetis AM Katzenellenbogen JR JM AM MBBS FRACP FAFPHM PhD FAHMS BSc (Occ Ther) BSc Hons (Epidemiol) MSc PhD Executive Director; Head, Strep A Translation; Co-Founder of REACH Honorary 08 6319 1000 contact@telethonkids.org.au ...

        Research

        A multicentre, retrospective audit of fosfomycin use for urinary tract infections in Australian children and adolescents

        Urinary tract infections (UTIs) due to MDR organisms are increasingly common. The lack of paediatric data on efficacious antibiotics makes UTI treatment particularly challenging. Data on the efficacy of fosfomycin use for UTI in children are variable. ...

        Research

        Core protocol for the adaptive Platform Trial In COVID-19 Vaccine priming and BOOsting (PICOBOO)

        The need for coronavirus 2019 (COVID-19) vaccination in different age groups and populations is a subject of great uncertainty and an ongoing global debate. Critical knowledge gaps regarding COVID-19 vaccination include the duration of protection offered by different priming and booster vaccination regimens in different populations, including homologous or heterologous schedules. ...

        Research

        Real world impact of 13vPCV in preventing invasive pneumococcal pneumonia in Australian children: A national study

        We aimed to assess the direct protective effect of 13 valent pneumococcal conjugate vaccine (13vPCV) against invasive pneumococcal pneumonia (IPP; including pneumonia and empyema) in children using a nation-wide case-control study across 11 paediatric tertiary hospitals in Australia. ...

        Research

        Protocol for delivery of intraoperative immunotherapy to mice by surgical debulking of subcutaneous tumors

        Pre-clinical studies developing novel therapies to prevent cancer recurrence require appropriate surgical models. Here, we present a protocol for surgical debulking of subcutaneous tumors in mice, which allows for intraoperative application of immunotherapy-loaded biomaterials.  ...

        Research

        "Hurts less, lasts longer"; a qualitative study on experiences of young people receiving high-dose subcutaneous injections of benzathine penicillin G to prevent rheumatic heart disease in New Zealand

        Four-weekly intramuscular benzathine penicillin G injections to prevent acute rheumatic fever progression have remained unchanged since 1955. A Phase-I trial in healthy volunteers demonstrated the safety and tolerability of high-dose subcutaneous infusions of BPG which resulted in a much longer effective penicillin exposure, and fewer injections. Here we describe the experiences of young people living with ARF participating in a Phase-II trial of SubCutaneous Injections of BPG. ...

        Research

        Research opportunities for the primary prevention and management of acute rheumatic fever and rheumatic heart disease: a National Heart, Lung, and Blood Institute workshop report

        Primary prevention of acute rheumatic fever (ARF) and rheumatic heart disease (RHD) encompasses the timely diagnosis and adequate treatment of the superficial group A Streptococcus (GAS) infections pharyngitis and impetigo. GAS is the only known inciting agent in the pathophysiology of the disease. ...

        Research

        Pertussis Disease and Antenatal Vaccine Effectiveness in Australian Children

        Population-level studies of severe pertussis extending beyond infancy are sparse, and none in the context of antenatal vaccination. We compared hospitalized pertussis cases from birth to 15 years of age before and after introduction of antenatal immunization. ...

        Research

        A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1

        To identify new susceptibility loci for psoriasis, we undertook a genome-wide association study of 594,224 SNPs in 2,622 individuals with psoriasis... ...

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