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        Circulating Epithelial Cell Cytokines Are Associated With Early-Onset Atopic Dermatitis

        Debbie Susan Palmer Prescott D SL BSc BND PhD MBBS BMedSci PhD FRACP Head, Early Life & Life-Course Health Program; Team Lead, Nutrition in Early Life Honorary Research Fellow debbie.palmer@uwa.edu.au susan.prescott@telethonkids.org.au Head, Early ...

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        Systematic In Vitro Evaluation of a Library of Approved and Pharmacologically Active Compounds for the Identification of Novel Candidate Drugs for KMT2A-Rearranged Leukemia

        Patients whose leukemias harbor a rearrangement of the Mixed Lineage Leukemia (MLL/KMT2A) gene have a poor prognosis, especially when the disease strikes in infants. The poor clinical outcome linked to this aggressive disease and the detrimental treatment side-effects, particularly in children, warrant the urgent development of more effective and cancer-selective therapeutics. ...

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        Levels of pneumococcal conjugate vaccine coverage and indirect protection against invasive pneumococcal disease and pneumonia hospitalisations in Australia: An observational study

        There is limited empiric evidence on the coverage of pneumococcal conjugate vaccines (PCVs) required to generate substantial indirect protection. We investigate the association between population PCV coverage and indirect protection against invasive pneumococcal disease (IPD) and pneumonia hospitalisations among undervaccinated Australian children. ...

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        BAL Inflammatory Markers Can Predict Pulmonary Exacerbations in Children With Cystic Fibrosis

        Pulmonary exacerbations in cystic fibrosis are characterized by airway inflammation and may cause irreversible lung damage. Early identification of such exacerbations may facilitate early initiation of treatment, thereby potentially reducing long-term morbidity. Research question: Is it possible to predict pulmonary exacerbations in children with cystic fibrosis, using inflammatory markers obtained from BAL fluid? ...

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        Multi-Omic Data Integration Allows Baseline Immune Signatures to Predict Hepatitis B Vaccine Response in a Small Cohort

        Vaccination remains one of the most effective means of reducing the burden of infectious diseases globally. Improving our understanding of the molecular basis for effective vaccine response is of paramount importance if we are to ensure the success of future vaccine development efforts. We applied cutting edge multi-omics approaches to extensively characterize temporal molecular responses following vaccination with hepatitis B virus (HBV) vaccine. Data were integrated across cellular, epigenomic, transcriptomic, proteomic, and fecal microbiome profiles, and correlated to final HBV antibody titres. ...

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        Ovalbumin in breast milk is associated with a decreased risk of IgE-mediated egg allergy in children

        Showed for the first time that the presence of an egg-derived allergen in breast milk is associated with a reduced risk of egg allergy in children at 2.5 years of age ...

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        BCG vaccination-induced emergency granulopoiesis provides rapid protection from neonatal sepsis

        We found that BCG, in a mouse model of neonatal polymicrobial sepsis, induced granulocyte colony-stimulating factor (G-CSF) within hours of administration ...

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        Living liveable? RESIDE's evaluation of the “Liveable Neighborhoods” planning policy on the health supportive behaviors and wellbeing of residents in Perth

        New suburban communities built in accordance with the “Liveable Neighbourhoods” policy have the potential to encourage health supportive behaviors ...

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        Racial discrimination and child and adolescent health in longitudinal studies: A systematic review

        This review emphasises the need to gain evidence for the mechanisms linking early racism exposure to adverse health outcomes in later life ...

        Research

        Timeliness of signal detection for adverse events following influenza vaccination in young children: a simulation case study

        Active vaccine safety surveillance leading to rapid detection of a safety signal would likely have resulted in earlier suspension of Fluvax from the vaccination programme ...

        Research

        Maternal Fiber Dietary Intakes during Pregnancy and Infant Allergic Disease

        Maternal resistant starch consumption was differentially associated with infant phenotypes, with reduced risk of infant wheeze, but increased risk of eczema ...

        Research

        Golden Age of Medicine 2.0: Lifestyle Medicine and Planetary Health Prioritized

        We emphasize that barriers to planetary health and the clinical application of lifestyle medicine are maintaining an unhealthy status quo ...

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