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        925-936 of 1772 results for 'early life'

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        The diagnosis of autism in a female: could it be Rett syndrome?

        The aims of this study were to compare the early and subsequent clinical courses of female subjects with Rett syndrome categorised by whether... ...

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        Children’s regenerative and genetic medicine program

        André Anthony Stephen Schultz Kicic Stick AS A SM MBChB, PhD, FRACP BSc (Hons) PhD MB BChir PhD MRCP FRACP Program Head, Respiratory Health RFA Rothwell Family Fellow; Head, Airway Epithelial Research Head, P4 Respiratory Health for Kids ...

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        Transfers of disadvantage across three generations using latent class associations within families

        There is a large volume of research on the persistence of advantage and disadvantage across generations. Intergenerational studies typically address family resources as independent factors, which ignores how risks cluster together and accumulate over time. ...

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        Investigating the effects of macrolides on excessive synthesis and secretion of airway mucins using novel ex vivo and in vivo approaches

        Alexander Larcombe A BScEnv (Hons) PhD Team Leader, Respiratory Environmental Health Team Leader, Respiratory Environmental Health Associate Professor Alexander Larcombe began work at the Telethon Institute in 2005 and is now a Senior Research ...

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        Patient-advocate-led global coalition adapting fit-for-purpose outcomes measures to assure meaningful inclusion of DEEs in clinical trials

        Existing clinical tools that measure non-seizure outcomes lack the range and granularity needed to capture skills in developmental and epileptic encephalopathy (DEE)-affected individuals who also fall in the severe to profound range of intellectual disability. This effectively excludes those with severe impairments from clinical trials, impeding the ability of sponsors to evaluate disease-modifying therapies. ...

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        Azithromycin inhibits mucin secretion, mucous metaplasia, airway inflammation, and airways hyperresponsiveness in mice exposed to house dust mite extract

        Excessive production, secretion, and retention of abnormal mucus is a pathological feature of many obstructive airways diseases including asthma. Azithromycin is an antibiotic that also possesses immunomodulatory and mucoregulatory activities, which may contribute to the clinical effectiveness of azithromycin in asthma. ...

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        Strengths and challenging behaviors in children and adolescents with Prader-Willi syndrome: Two sides to the coin

        Prader-Willi Syndrome (PWS) is a rare genetic disorder associated with emotional/behavioral disturbances. These difficulties are well documented in the literature, but the positive attributes of these individuals are not described. ...

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        The mechanism of deep inspiration-induced bronchoprotection: Evidence from a mouse model

        In healthy individuals, deep inspirations (DIs) taken prior to a bronchial challenge reduce the bronchoconstrictor response, which is termed... ...

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        Exposure to Ultraviolet Radiation in the Modulation of Human Diseases

        This review focuses primarily on the beneficial effects for human health of exposure to ultraviolet radiation ...

        Research

        Longitudinal effects of dog ownership, dog acquisition, and dog loss on children’s movement behaviours: findings from the PLAYCE cohort study

        Regular physical activity is important for children's physical and mental health, yet many children do not achieve recommended amounts of physical activity. Dog ownership has been associated with increased physical activity in children, however, there have been no longitudinal studies examining this relationship. ...

        Research

        Conceptualizing a quality of life framework for girls with Rett syndrome using qualitative methods

        Existing quality of life scales for children in the general population or with other disabilities did not capture the QOL of children with Rett syndrome ...

        Research

        Relationships between depression and anxiety symptoms scores and blood pressure in young adults

        This study aimed to assess the relationships among BP, depression and anxiety symptom scores and self-reported history of depression in young adults. ...

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