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        Romidepsin enhances the efficacy of cytarabine in vivo, revealing HDAC inhibition as a therapeutic strategy for KMT2A-rearranged acute lymphoblastic leukemia

        In this study, we investigate the in vivo synergy between romidepsin and cytarabine ...

        Research

        Challenges posed by COVID-19 to children with cancer

        Development of standardised guidance by national and regional authorities for reducing the risk of SARS-CoV-2 transmission to children with cancer ...

        Research

        A Novel Missense Mutation Affecting the N-terminal Domain of SAP Protein in X-linked Lymphoproliferative Disease

        We have revealed a novel SH2D1A gene mutation in a patient with XLP resulting in fulminant refractory EBV-driven HLH, which is a recognized severe complication ...

        Research

        Methotrexate-related central neurotoxicity: clinical characteristics, risk factors and genome-wide association study in children treated for acute lymphoblastic leukemia

        Symptomatic methotrexate-related central neurotoxicity (MTX neurotoxicity) is a severe toxicity experienced during acute lymphoblastic leukemia (ALL) therapy with potential long-term neurologic complications. Risk factors and long-term outcomes require further study. ...

        Research

        The Bone Marrow Microenvironment in B-Cell Development and Malignancy

        B lymphopoiesis is characterized by progressive loss of multipotent potential in hematopoi-etic stem cells, followed by commitment to differentiate into B cells, which mediate the humoral response of the adaptive immune system. ...

        Research

        Therapeutic targeting of the leukaemia microenvironment

        In recent decades, the conduct of uniform prospective clinical trials has led to improved remission rates and survival for patients with acute myeloid leukaemia and acute lymphoblastic leukaemia. However, high-risk patients continue to have inferior outcomes, where chemoresistance and relapse are common due to the survival mechanisms utilised by leukaemic cells. ...

        Research

        Immunogenicity and safety of single-dose, 13-valent pneumococcal conjugate vaccine in pediatric and adolescent oncology patients

        All children who are receiving therapy for cancer should receive a single dose of PCV13 as soon as possible after diagnosis, regardless of prior PCV exposure. ...

        Research

        Heterogeneity in mechanisms of emergent resistance in pediatric T-cell acute lymphoblastic leukemia

        Biological changes associated with T-ALL relapse and resistance are stochastic and highly individual ...

        Research

        Novel CT domain-encoding splice forms of CTGF/CCN2 are expressed in B-lineage acute lymphoblastic leukaemia

        Connective tissue growth factor (CTGF/CCN2) has been shown previously to be aberrantly expressed in a high proportion of paediatric precursor B cell acute... ...

        Research

        Bioenergetic modulation overcomes glucocorticoid resistance in T-lineage acute lymphoblastic leukaemia

        Drug-resistant forms of acute lymphoblastic leukaemia (ALL) are a leading cause of death from disease in children. ...

        Research

        Hypomethylation of the CTGF gene locus is a common feature of paediatric pre-B acute lymphoblastic leukaemia

        We identified consistent hypomethylation of the CTGF locus in primary pre-B ALL specimens regardless of CTGF expression. ...

        Research

        Validation of a mouse xenograft model system for gene expression analysis of human acute lymphoblastic leukaemia

        Pre-clinical models that effectively recapitulate human disease are critical for expanding our knowledge of cancer biology and drug resistance mechanisms. ...

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