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        Macrophage infectivity potentiator protein, a peptidyl prolyl cis-trans isomerase, essential for Coxiella burnetii growth and pathogenesis

        Coxiella burnetii is a Gram-negative intracellular pathogen that causes the debilitating disease Q fever, which affects both animals and humans. The only available human vaccine, Q-Vax, is effective but has a high risk of severe adverse reactions, limiting its use as a countermeasure to contain outbreaks. Therefore, it is essential to identify new drug targets to treat this infection. ...

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        The risk of intramuscular haematoma is low following injection of benzathine penicillin G in patients receiving concomitant anticoagulant therapy

        Our local data supports continuing intramuscular injection of BPG in patients with rheumatic heart disease receiving anticoagulant medication ...

        Research

        Cyberbullying and the role of the law in Australian schools: Views of senior officials

        Opinions of employees from the education and legal systems, regarding their perceptions of the role of the law and cyberbullying in Australian schools ...

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        Genotype and phenotype spectrum of NRAS germline variants

        Here we describe 19 new cases with RASopathy due to disease-causing variants in NRAS ...

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        Outcomes of nontransitioned cases in a sample at ultra-high risk for psychosis.

        Two-thirds of individuals identified as at ultra-high risk for psychosis do not develop psychotic disorder over the medium term. ...

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        Lung function and exhaled nitric oxide in healthy unsedated African infants

        Population-appropriate lung function reference data are essential to accurately identify respiratory disease and measure response to interventions. ...

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        Nirsevimab binding-site conservation in respiratory syncytial virus fusion glycoprotein worldwide between 1956 and 2021: an analysis of observational study sequencing data

        Nirsevimab is an extended half-life monoclonal antibody to the respiratory syncytial virus (RSV) fusion protein that has been developed to protect infants for an entire RSV season. Previous studies have shown that the nirsevimab binding site is highly conserved. However, investigations of the geotemporal evolution of potential escape variants in recent (ie, 2015–2021) RSV seasons have been minimal. ...

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        Autoimmune antibodies and asbestos exposure: Evidence from Wittenoom, Western Australia

        This study is the first to report increased anti-nuclear antibodies positivity among persons exposed exclusively to crocidolite ...

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        Factors associated with trajectories of psychological distress for Australian fathers across the early parenting period

        Early postnatal factors associated with fathers' persistent distress were identified, providing opportunities for early identification and targeted early... ...

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        Sun exposure and vitamin D status as northeast asian migrants become acculturated to life in Australia

        Targeted public health approaches are required to manage the high prevalence of vitamin D deficiency in migrants retaining a traditional lifestyle ...

        Research

        Multiple risk exposures for reading achievement in childhood and adolescence

        Across 6 years of school, multiple risk-exposed children lagged behind low risk-exposed children in the order of years of lost gains in reading achievement ...

        Research

        Immune responses to a recombinant, four-component, meningococcal serogroup B vaccine (4CMenB) in adolescents

        This trial evaluated the lot consistency, early immune responses and safety of the vaccine against serogroup B Neisseria meningitidis (4CMenB) - in 11 to 17... ...

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