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        Angiogenesis-associated pathways play critical roles in neonatal sepsis outcomes

        Neonatal sepsis is a major cause of childhood mortality. Limited diagnostic tools and mechanistic insights have hampered our abilities to develop prophylactic or therapeutic interventions. Biomarkers in human neonatal sepsis have been repeatedly identified as associated with dysregulation of angiopoietin signaling and altered arachidonic acid metabolism.  ...

        Research

        Impacts of armed conflicts on tuberculosis burden and treatment outcomes: a systematic review

        This systematic review aimed to summarise existing literature on the impacts of armed conflicts on tuberculosis burden and treatment outcomes. ...

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        An economic case for a vaccine to prevent group A streptococcus skin infections

        A vaccine that prevents GAS cellulitis and other skin infections, in addition to throat infections, would maximise its value and commercial viability ...

        Research

        Developing and characterising juvenile models of aggressive paediatric brain cancers for the evaluation of novel immunotherapies.

        Raelene Nick Jessica Annabel Meegan Jacqueline Endersby Golding Buck Short Howlett Whitehouse R NG JB AS MH JW BSc (Hons) PhD BSc DPhil DPhil BMedRes (hons), PhD BSc(Hons), PhD BSc (Hons), PhD Brainchild Fellow; Co-Head, Brain Tumour Research ...

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        PLAYCE 2 School: Moving well for optimal child health and development

        Hayley Liz Gina Pulan Zino Christian Wenden Trapp Bai Phiri HC LW GT PB ZP BSc (1st Class Hons), PhD W.Aust. BHlthSc MPH BHSc(Hons1A), RPHNutr, PhD BSc, MPH BSc Program Head, Healthy Behaviours and Environments; National Heart Foundation Future ...

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        Supporting parents with young children to create healthy screen time behaviours

        Mary Amy Gina Bec Brushe Finlay-Jones Trapp Young MB AFJ GT BY BPsych(Hons), PhD (Public Health) BPsych(Hons), MPsych(Clinical), MHealthEcon, PhD (Clin Psych) BHSc(Hons1A), RPHNutr, PhD BSc Nursing, Grad Cert Clinical Nursing, M Mental Health ...

        Research

        Transforming Families

        Yael Penelope Helen Holly Perry Strauss Morgan Moss YP PS HM HM BPsych (Hons) MPsych (Clin) PhD BA, MPH, PhD BA (Hons), Doctor of Psychology BEd Program Head, Mental Health & Youth; Head, Youth Mental Health Research Fellow in Youth Suicide ...

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        IRF7-Associated Immunophenotypes Have Dichotomous Responses to Virus/Allergen Coexposure and OM-85-Induced Reprogramming

        High risk for virus-induced asthma exacerbations in children is associated with an IRF7lo immunophenotype, but the underlying mechanisms are unclear. Here, we applied a Systems Biology approach to an animal model comprising rat strains manifesting high versus low susceptibility to experimental asthma, induced by virus/allergen coexposure, to elucidate the mechanism(s)-of-action of the high-risk asthma immunophenotype. ...

        Research

        Aboriginal and Torres Strait Islander Partnerships to Prevent Permanent Lung Disease (APPLE Study)

        André Schultz AS MBChB, PhD, FRACP Program Head, Respiratory Health RFA Program Head, Respiratory Health RFA Prof André Schultz is the Program Head of Respiratory Health and Head of the BREATH Team at Telethon Kids Institute. He is passionate ...

        Research

        Prevalence of chronic wet cough, protracted bacterial bronchitis (PBB) and middle ear disease in the Kimberley

        André Schultz AS MBChB, PhD, FRACP Program Head, Respiratory Health RFA Program Head, Respiratory Health RFA Prof André Schultz is the Program Head of Respiratory Health and Head of the BREATH Team at Telethon Kids Institute. He is passionate ...

        Research

        Inflammation induces α1-adrenoceptor expression in peripheral blood mononuclear cells of patients with complex regional pain syndrome

        Persistent regional and systemic inflammation may promote pain and hyperalgesia in complex regional pain syndrome. In this study, we investigated whether stimulation of α1-adrenoceptors on peripheral blood mononuclear cells might contribute to this inflammatory state. ...

        Research

        Retinoic Acid Induces an IFN-Driven Inflammatory Tumour Microenvironment, Sensitizing to Immune Checkpoint Therapy

        With immune checkpoint therapy (ICT) having reshaped the treatment of many cancers, the next frontier is to identify and develop novel combination therapies to improve efficacy. Previously, we and others identified beneficial immunological effects of the vitamin A derivative tretinoin on anti-tumour immunity. ...

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