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        85-96 of 521 results for 'Growth'

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        Validation of a model for optimal birth weight: A prospective study using serial ultrasounds

        The aim of this study was to validate a model for optimal birth weight derived from neonatal records, and to test the assumption that preterm births may be... ...

        Research

        Antecedents of cerebral palsy and perinatal death in term and late preterm singletons

        The odds of total cerebral palsy after potentially asphyxial birth events or inflammation were modestly increased. ...

        Research

        Defining the role of common variation in the genomic and biological architecture of adult human height

        Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability... ...

        Research

        Genomic analyses in Cornelia de Lange Syndrome and related diagnoses: Novel candidate genes, genotype–phenotype correlations and common mechanisms

        Cornelia de Lange Syndrome (CdLS) is a rare, dominantly inherited multisystem developmental disorder characterized by highly variable manifestations of growth and developmental delays, upper limb involvement, hypertrichosis, cardiac, gastrointestinal, craniofacial, and other systemic features. ...

        Research

        The longitudinal microbial and metabolic landscape of infant cystic fibrosis: the gut-lung axis

        In cystic fibrosis, gastrointestinal dysfunction and lower airway infection occur early and are independently associated with poorer outcomes in childhood. This study aimed to define the relationship between the microbiota at each niche during the first 2 years of life, its association with growth and airway inflammation, and explanatory features in the metabolome.  ...

        Research

        Australian guidelines for the management of children with achondroplasia

        Achondroplasia is the most common form of skeletal dysplasia. In addition to altered growth, children and young people with achondroplasia may experience medical complications, develop and function differently to others and require psychosocial support. International, European and American consensus guidelines have been developed for the management of achondroplasia. The Australian focused guidelines presented here are designed to complement those existing guidelines. ...

        Research

        Ndrg1 in development and maintenance of the myelin sheath

        CMT4D disease is a severe autosomal recessive demyelinating neuropathy with extensive axonal loss leading to early disability, caused by mutations... ...

        Research

        MYCN sensitizes neuroblastoma to the MDM2-p53 antagonists Nutlin-3 and MI-63

        We hypothesized that reactivation of p53 by inhibition of its negative regulator will result in p53-mediated growth arrest and apoptosis. ...

        Research

        Net benefit of smaller human populations to environmental integrity and individual health and wellbeing

        The global human population is still growing such that our collective enterprise is driving environmental catastrophe. Despite a decline in average population growth rate, we are still experiencing the highest annual increase of global human population size in the history of our species-averaging an additional 84 million people per year since 1990. ...

        Research

        Techniques and Processes Involved in Nanoencapsulation of Omega-3, -6, and -9 Fatty Acids

        Omega fatty acids are essential for young children’s growth and development. They also have essential functions in cell receptors of membranes and regulation of hormones synthesis. Essential fatty acids such as omega-3 and -6 can only be obtained through food mainly fish and other seafood and to a lesser extent through nuts, seeds, and plant oils. ...

        Research

        Revisiting the inoculum effect for Streptococcus pyogenes with a hollow fibre infection model

        Severe, invasive Streptococcus pyogenes (Strep A) infections result in greater than 500,000 deaths annually. First line treatment for such infections is benzylpenicillin, often with the addition of clindamycin, but treatment failure can occur with this regimen. This failure has been partially attributed to the inoculum effect, which presents as reduced antibiotic susceptibility during high bacterial density and plateau-phase growth. ...

        Research

        Joint developmental trajectories of internalizing and externalizing problems from mid-childhood to late adolescence and childhood risk factors: Findings from a prospective pre-birth cohort

        There is limited evidence on heterogenous co-developmental trajectories of internalizing and externalizing problems from childhood to adolescence and predictors of these joint trajectories. We utilized longitudinal data from Raine Study participants to identify these joint trajectories from 5 to 17 years using parallel-process latent class growth analysis and analyze childhood individual and family risk factors predicting these joint trajectories using multinomial logistic regression. ...

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