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        85-96 of 115 results for 'Professor Stephen Stick'

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        Vulnerable from the first breath - epithelial dysfunction and respiratory outcomes in children

        Anthony David Stephen Susan Kicic Martino Stick Prescott A DM SM SL BSc (Hons) PhD BSc PhD MB BChir PhD MRCP FRACP MBBS BMedSci PhD FRACP Rothwell Family Fellow; Head, Airway Epithelial Research Head, Clinical Epigenetics Head, P4 Respiratory Health ...

        Research

        Effect of posture on lung ventilation distribution and associations with structure in children with cystic fibrosis

        Background: We assessed the effect of posture on ventilation distribution and the impact on associations with structural lung disease. ...

        Research

        Air trapping in early cystic fibrosis lung disease-Does CT tell the full story?

        Mosaic attenuation on expiratory chest computed tomography (CT) is common in early life cystic fibrosis (CF) and often referred to as "air trapping" ...

        Research

        DNA Methylation Profiles of Airway Epithelial Cells and PBMCs from Healthy, Atopic and Asthmatic Children

        Allergic inflammation is commonly observed in a number of conditions that are associated with atopy including asthma, eczema and rhinitis. ...

        Research

        Regional Differences in Susceptibiity of Bronchial Epithelium to Mesenchymal Transition and Inhibition by the Macrolide Antibiotic Azithromycin

        Dysregulated repair following epithelial injury is a key forerunner of disease in many organs, and the acquisition of a mesenchymal phenotype by the injured... ...

        Research

        Hypoxia and sterile inflammation in cystic fibrosis airways: Mechanisms and potential therapies

        In this review, we consider recent evidence regarding hypoxia and sterile inflammation in cystic fibrosis airways ...

        Research

        Alpha-1 antitrypsin mitigates the inhibition of airway epithelial cell repair by neutrophil elastase

        Free NE activity is deleterious for epithelial homeostasis and support the hypothesis that proteases in the airway contribute to CF structural lung disease ...

        Research

        Exploring the Complexity of the Human Respiratory Virome through an In Silico Analysis of Shotgun Metagenomic Data Retrieved from Public Repositories

        Respiratory viruses significantly impact global morbidity and mortality, causing more disease in humans than any other infectious agent. Beyond pathogens, various viruses and bacteria colonize the respiratory tract without causing disease, potentially influencing respiratory diseases’ pathogenesis. ...

        Research

        AI-Driven Cell Tracking to Enable High-Throughput Drug Screening Targeting Airway Epithelial Repair for Children with Asthma

        The airway epithelium of children with asthma is characterized by aberrant repair that may be therapeutically modifiable. The development of epithelial-targeting therapeutics that enhance airway repair could provide a novel treatment avenue for childhood asthma. ...

        Research

        Blocking Notch3 Signaling Abolishes MUC5AC Production in Airway Epithelial Cells from Asthmatics

        We demonstrate that NOTCH3 is a regulator of MUC5AC production ...

        Research

        Assessing the unified airway hypothesis in children via transcriptional profiling of the airway epithelium

        Upper and lower airways are conserved in their transcriptional composition, and variations associated with disease are present in both nasal and tracheal epithelium ...

        Research

        Airway epithelial repair in health and disease: Orchestrator or simply a player?

        This review attempts to highlight migration-specific and cell-extracellular matrix (ECM) aspects of repair used by epithelial cells ...

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