DYRK1A is a serine/threonine kinase encoded on human chromosome 21 (HSA21) that has been implicated in several pathologies of Down syndrome (DS), including cognitive deficits and Alzheimer's disease. Although children with DS are predisposed to developing leukemia, especially B cell acute lymphoblastic leukemia (B-ALL), the HSA21 genes that contribute to malignancies remain largely undefined. Here, we report that DYRK1A is overexpressed and required for B-ALL. Genetic and pharmacologic inhibition of DYRK1A decreased leukemic cell expansion and suppressed B-ALL development in vitro and in vivo. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• January 2021

Standards and consensus recommendations are presented for manufacturers, clinicians, operators, and researchers ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• October 2019

Forced oscillation technique measurements were feasible in Emirati school-children. New forced oscillation technique reference equation in Emirati children were derived. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• July 2018

This JAK3A572V knockin model is a relevant new tool for testing the efficacy of JAK inhibitors in JAK3-related hematopoietic malignancies ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• July 2018

This international task force report updates general considerations for bronchial challenge testing and the performance of the methacholine challenge test. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• May 2017

André Schultz AS MBChB, PhD, FRACP Program Head, Respiratory Health RFA Program Head, Respiratory Health RFA Prof André Schultz is the Program Head of Respiratory Health and Head of the BREATH Team at Telethon Kids Institute. He is passionate ...

• 1. Telethon Kids Institute
• Projects

The Global Lung Function ‘Caucasian’ and ‘Other’ spirometry equations do not match healthy Aboriginal FEV1 and FVC data ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• August 2019

Developing a FeNO test that is affordable enough to allow daily measurements, patients will be able to access quantifiable data to assist them to monitor their asthma ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• August 2019

Although formaldehyde concentrations were very low, this finding is consistent with other studies of formaldehyde and poor birth outcomes ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• April 2019

Cerebral palsy (CP) is a physical disability that affects movement and posture. Approximately 17 million people worldwide and 34,000 people in Australia are living with CP. In clinical and kinematic research, goniometers and inclinometers are the most commonly used clinical tools to measure joint angles and positions in children with CP. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• October 2021

Transcription factors known to induce the epithelial-to-mesenchymal transition (EMT) (such as ZEB1/2 [zinc finger E-box binding homeobox 1/2], SNAI1/2/3, and TWIST1/2) have been undoubtedly implicated in tumorigenesis, cancer progression, metastasis, and chemoresistance in solid tumors; however, their role in normal and malignant hematopoiesis has been underappreciated for many years. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• August 2020

Anesthesiologists should consider using an intravenous propofol induction technique in children who are at high risk of experiencing perioperative respiratory adverse event ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• June 2018