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        85-96 of 112 results for 'mouse'

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        Persistent and compartmentalised disruption of dendritic cell subpopulations in the lung following influenza A virus infection

        Immunological homeostasis in the respiratory tract is thought to require balanced interactions between networks of dendritic cell (DC) subsets in lung... ...

        Research

        Suppression of adrenomedullin contributes to vascular leakage and altered epithelial repair during asthma

        The anti-inflammatory peptide, adrenomedullin (AM), and its cognate receptor are expressed in lung tissue, but its pathophysiological significance in airway... ...

        Research

        Sensitizing and Th2 Adjuvant Activity of Cysteine Protease Allergens

        Here, we report on a model that does not use Th2-skewing adjuvants and yet achieves sensitization solely via the nasal mucosa. ...

        Research

        Sensitization to immune checkpoint blockade through activation of a STAT1/NK axis in the tumor microenvironment

        Our results identify a pretreatment tumor microenvironment that predicts response to immune checkpoint blockade, which can be therapeutically attained ...

        Research

        Vitamin D deficiency causes airway hyperresponsiveness and increases airway smooth muscle mass in the lungs of female BALB/c mice

        We tested whether there is a causal association between vitamin D deficiency, airway smooth muscle (ASM) mass, and the development of airway hyperresponsiveness ...

        Research

        ONC201 in Combination with Paxalisib for the Treatment of H3K27-Altered Diffuse Midline Glioma

        Diffuse midline gliomas (DMG), including diffuse intrinsic pontine gliomas (DIPG), are the most lethal of childhood cancers. Palliative radiotherapy is the only established treatment, with median patient survival of 9 to 11 months. ONC201 is a DRD2 antagonist and ClpP agonist that has shown preclinical and emerging clinical efficacy in DMG.  ...

        Research

        A pathogenic role for the integrin CD103 in experimental allergic airways disease

        Role for CD103 in the pathogenesis of experimental allergic airways disease in BALB/c mice through local control of CD4+ T cell and DC subset recruitment ...

        Research

        Sub-erythemal ultraviolet radiation reduces metabolic dysfunction in already overweight mice

        Exposure to sunlight may limit cardiometabolic risk. ...

        Research

        Expanding the clinical picture of the MECP2 Duplication syndrome

        Perinatal characteristics, early childhood development and medical co-morbidities in MECP2 Duplication syndrome ...

        Research

        Developing and characterising juvenile models of aggressive paediatric brain cancers for the evaluation of novel immunotherapies.

        Raelene Nick Jessica Annabel Meegan Jacqueline Endersby Golding Buck Short Howlett Whitehouse R NG JB AS MH JW BSc (Hons) PhD BSc DPhil DPhil BMedRes (hons), PhD BSc(Hons), PhD BSc (Hons), PhD Brainchild Fellow; Co-Head, Brain Tumour Research ...

        Research

        Medulloblastoma Down Under 2013: a report from the third annual meeting of the International Medulloblastoma Working Group

        Medulloblastoma is curable in approximately 70 % of patients. Over the past decade, progress in improving survival using conventional therapies has stalled... ...

        Research

        Developing new immune based therapies for neuroblastoma

        Alison Linda W. Joost Omar McDonnell Wijaya Lesterhuis Elaskalani AM LW WJL OE BSc (Hons), PhD BSc PhD BSc, MSc, PhD Early Career Fellow Postdoctoral Researcher Program Head, Cancer; Chronic and Severe Diseases RFA Deputy Head Senior Research ...

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