Atopic diseases are the most common chronic conditions of childhood. The apparent rise in food anaphylaxis in young children over the past three decades is of particular concern, owing to the lack of proven prevention strategies other than the timely introduction of peanut and egg. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• September 2021

Rhinovirus (RV) C can cause asymptomatic infection and respiratory illnesses ranging from the common cold to severe wheezing. The aim was to identify how age and other individual-level factors are associated with susceptibility to RV-C illnesses. Longitudinal data from the COAST (Childhood Origins of Asthma) birth cohort study were analyzed to determine relationships between age and RV-C infections. Neutralizing antibodies specific for RV-A and RV-C (three types each) were determined using a novel PCR-based assay. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• April 2021

Impaired interferon response and allergic sensitization may contribute to virus-induced wheeze and asthma development in young children. Plasmacytoid dendritic cells play a key role in antiviral immunity as critical producers of type I interferons.  ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• December 2023

Dysregulated expression of IFN-dependent pathways after respiratory viral infections is a defining immunophenotypic feature of AVB-susceptible infants ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• June 2019

Australian infants who received whole-cell pertussis vaccines were less likely to be diagnosed with food allergy in childhood ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• June 2020

This protocol adapted an experimental animal model of disease for sensitization to ovalbumin during the immediate post-weaning period beginning at 21 days of age ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• March 2019

Atopic diseases are the most common chronic conditions of childhood. The apparent rise in food anaphylaxis in young children over the past three decades is of particular concern, owing to the lack of proven prevention strategies other than the timely introduction of peanut and egg. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• September 2021

Type 1 and 3 interferon response capacity appears strongly developmentally constrained at birth ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• March 2019

Here, we report on a model that does not use Th2-skewing adjuvants and yet achieves sensitization solely via the nasal mucosa. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• January 2012

Inhaled allergens are known for their immediate and ongoing effects in the respiratory tract (RT). ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2010
• August 2010

Current infant vaccination against pertussis in North America and Australia requires three doses of vaccines including diphtheria, tetanus and acellular... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2010
• March 2010

Early aberrant antibody responses, aeroallergen sensitised people, subclinical bacterial infection ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2010
• January 2010