Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• January 2011

The purpose of this review is to examine the role of innate immunity in the lungs in the development of allergy and asthma. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• January 2011

For 20 years, the hygiene hypothesis has dominated attempts to explain the increasing prevalence of allergic disease. A causal link between maternal innate immu ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2010
• November 2010

Shelley Prue Gorman Hart S PH BSc (Hons) PhD BSc (Hons) MSc PhD Honorary Research Associate Head, Inflammation shelley.gorman@telethonkids.org.au prue.hart@telethonkids.org.au Honorary Research Associate Head, Inflammation Shelley Gorman is a Group ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2010
• May 2010

In human asthma, and experimental allergic airways disease in mice, antigen-presenting cells and CD4(+) effector cells at the airway mucosa orchestrate, and CD4 ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2010
• May 2010

Pat Deborah Holt Strickland PG DH PhD, DSc, FRCPath, FRCPI, FAA PhD Emeritus Honorary Researcher Program Head, Immunobiology and Immunotherapeutic Program Patrick.Holt@telethonkids.org.au Deb.Strickland@telethonkids.org.au Emeritus Honorary ...

• 1. Telethon Kids Institute
• Our research
• Past teams
• Human Immunology

Pat Deborah Holt Strickland PG DH PhD, DSc, FRCPath, FRCPI, FAA PhD Emeritus Honorary Researcher Program Head, Immunobiology and Immunotherapeutic Program Patrick.Holt@telethonkids.org.au Deb.Strickland@telethonkids.org.au Emeritus Honorary ...

• 1. Telethon Kids Institute
• Our research
• Early Environment
• Immunobiology & Immunotherapeutic Program
• Pregnancy and Early Life Immunology

Long-standing health inequalities in Australian society that were exposed by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic were described as "fault lines" in a recent call to action by a consortium of philanthropic organizations. With asthma a major contributor to childhood disease burden, studies of its spatial epidemiology can provide valuable insights into the emergence of health inequalities early in life. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• February 2024

High risk for virus-induced asthma exacerbations in children is associated with an IRF7lo immunophenotype, but the underlying mechanisms are unclear. Here, we applied a Systems Biology approach to an animal model comprising rat strains manifesting high versus low susceptibility to experimental asthma, induced by virus/allergen coexposure, to elucidate the mechanism(s)-of-action of the high-risk asthma immunophenotype. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• July 2021

Asthma exacerbations in children can be divided into IRF7hi versus IRF7lo phenotypes with associated differences in clinical phenotypes ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• March 2019

Children of East Asian ancestry born in Australia have a higher burden of most allergic diseases in the first 6 years of life, whereas asthma may follow a different pattern ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• February 2019

Spacer device was not associated with clinically important differences in lung function following bronchodilator inhalation in children with asthma ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• May 2019