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        949-960 of 1360 results for '2018'

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        Characteristics of TCR Repertoire Associated With Successful Immune Checkpoint Therapy Responses

        Immunotherapies have revolutionized cancer treatment. In particular, immune checkpoint therapy (ICT) leads to durable responses in some patients with some cancers. However, the majority of treated patients do not respond. Understanding immune mechanisms that underlie responsiveness to ICT will help identify predictive biomarkers of response and develop treatments to convert non-responding patients to responding ones. ICT primarily acts at the level of adaptive immunity. The specificity of adaptive immune cells, such as T and B cells, is determined by antigen-specific receptors. ...

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        Controlled human infection for vaccination against Streptococcus pyogenes (CHIVAS): Establishing a group A Streptococcus pharyngitis human infection study

        We review the Group A Streptococcus Human infection studies and present the study protocol for a dose-ranging inpatient study in healthy adults ...

        Research

        Functional genomics in cancer immunotherapy: Computational approaches for biomarker and drug discovery

        This review explores computational strategies to yield biological insight into the processes involved in the immunotherapeutic response ...

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        Validation of monoclonal anti-PKC isozyme antibodies for flow cytometry analyses in human T cell subsets and expression in cord blood T cells

        We have undertaken to validating the specificity of commercially available antibodies marketed for flow cytometry to measure PKCα, βI, βII, δ, ε, η, θ, ζ, ι/λ and μ ...

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        An economic case for a vaccine to prevent group A streptococcus skin infections

        A vaccine that prevents GAS cellulitis and other skin infections, in addition to throat infections, would maximise its value and commercial viability ...

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        Primary prevention of rheumatic fever in the 21st century: evaluation of a national programme

        Population-based primary prevention of ARF through sore throat management may be effective in well-resourced settings like New Zealand ...

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        Global supermarkets' corporate social responsibility commitments to public health: A content analysis

        Investigate the world's largest and most powerful supermarkets' publically available CSR commitments to determine their potential impact on public health ...

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        Rheumatic heart disease in pregnancy: How can health services adapt to the needs of Indigenous women? A qualitative study

        Health systems did not meet the needs of pregnant Aboriginal women with rheumatic heart disease ...

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        Comparative analyses of whole genome sequences of Leishmania infantum isolates from humans and dogs in northeastern Brazil

        Overall the analyses do not suggest individual sequence variants account for differences in clinical outcome or adaptation to different hosts. ...

        Research

        Viral etiology and the impact of codetection in young children presenting with influenza-like illness

        Children with acute respiratory tract infection (ARTI) frequently exhibit virus-virus codetection, yet the clinical significance of ARTI remains contentious. ...

        Research

        Bugging allergy; role of pre-, pro- and synbiotics in allergy prevention

        Here, we summarize and discuss findings of randomized clinical trials that have examined the effects of these strategies on short and long-term. ...

        Research

        Narrative Medicine Meets Planetary Health: Mindsets Matter in the Anthropocene

        We argue that the principles and practice of narrative medicine can be applied on a larger scale, one with planetary health in mind ...

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