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        Methotrexate-related central neurotoxicity: clinical characteristics, risk factors and genome-wide association study in children treated for acute lymphoblastic leukemia

        Symptomatic methotrexate-related central neurotoxicity (MTX neurotoxicity) is a severe toxicity experienced during acute lymphoblastic leukemia (ALL) therapy with potential long-term neurologic complications. Risk factors and long-term outcomes require further study. ...

        Research

        Preventing heart failure: a position paper of the Heart Failure Association in collaboration with the European Association of Preventive Cardiology

        The heart failure epidemic is growing and its prevention, in order to reduce associated hospital readmission rates and its clinical and economic burden, is a key issue in modern cardiovascular medicine. The present position paper aims to provide practical evidence-based information to support the implementation of effective preventive measures. ...

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        The Spectrum, Severity and Outcomes of Rheumatic Mitral Valve Disease in Pregnant Women in Australia and New Zealand

        Rheumatic heart disease (RHD) poses significant perinatal risks. We aimed to describe the spectrum, severity and outcomes of rheumatic mitral valve disease in pregnancy in Australia and New Zealand. ...

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        Acute rheumatic fever and rheumatic heart disease

        Acute rheumatic fever (ARF) is the result of an autoimmune response to pharyngitis caused by infection with group A Streptococcus. ...

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        Development of Group A streptococcal vaccines: an unmet global health need

        This review provides an update on the current status of Group A Streptococcus vaccine development, & describes global efforts to accelerate the development... ...

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        Hypertensive diseases of pregnancy predict parent-reported difficult temperament in infancy

        These data suggest that the link between maternal hypertensive diseases of pregnancy and child behavioral development begins in the first year of life. ...

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        Lactoferrin Expression Is Not Associated with Late-Onset Sepsis in Very Preterm Infants

        Preterm infants are at a high risk of developing late-onset sepsis (LOS). Lactoferrin is one of the most abundant endogenous antimicrobial proteins expressed in breast milk, stools, and blood, and a candidate for preventive intervention. Large clinical trials have recently investigated whether enteral supplementation with bovine lactoferrin reduces LOS. ...

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        Pharmacological ablation of the airway smooth muscle layer—Mathematical predictions of functional improvement in asthma

        Findings provide further proof of concept that pharmacological targeting of airway smooth muscle thickness will be beneficial and may be facilitated by azithromycin ...

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        Understanding obesity among companion dogs: New measures of owner's beliefs and behaviour and associations with body condition scores

        The findings provide a method for assessing a wide range of factors that may be associated with obesity among companion dogs ...

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        Exploring stakeholders' perceptions of the acceptability, usability, and dissemination of the australian 24-hour movement guidelines for the early years

        This study examined stakeholders' perceptions regarding the acceptability, usability, and dissemination of the Australian 24-Hour Movement Guidelines ...

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        Longitudinal effects of dog ownership, dog acquisition, and dog loss on children’s movement behaviours: findings from the PLAYCE cohort study

        Regular physical activity is important for children's physical and mental health, yet many children do not achieve recommended amounts of physical activity. Dog ownership has been associated with increased physical activity in children, however, there have been no longitudinal studies examining this relationship. ...

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        Fragranced consumer products: effects on asthmatic Australians

        Most asthmatics would prefer workplaces, healthcare facilities, and environments that are fragrance-free, which could help reduce adverse effects ...

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