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        Effect of early carriage of streptococcus pneumoniae on the development of pneumococcal protein-specific cellular immune responses in infancy

        The aim of this study was to examine the relationship between nasopharyngeal pneumococcal colonization in early life and the development of T cell responses. ...

        Research

        Vulnerable from the first breath - epithelial dysfunction and respiratory outcomes in children

        Anthony David Stephen Susan Kicic Martino Stick Prescott A DM SM SL BSc (Hons) PhD BSc PhD MB BChir PhD MRCP FRACP MBBS BMedSci PhD FRACP Rothwell Family Fellow; Head, Airway Epithelial Research Head, Clinical Epigenetics Head, P4 Respiratory Health ...

        Research

        Identifying pediatric lung disease: A comparison of forced oscillation technique outcomes

        These findings suggest the utility of specific FOT outcomes is dependent on the respiratory disease being assessed ...

        Research

        The challenges of developing and optimising an assay to measure 25-hydroxyvitamin D in saliva

        We have developed an LC-MS/MS assay that accurately measures saliva 25(OH)D3 levels, which correlated with serum levels ...

        Research

        Insights into the Clinical, Biological and Therapeutic Impact of Copy Number Alteration in Cancer

        Copy number alterations (CNAs), resulting from the gain or loss of genetic material from as little as 50 base pairs or as big as entire chromosome(s), have been associated with many congenital diseases, de novo syndromes and cancer. It is established that CNAs disturb the dosage of genomic regions including enhancers/promoters, long non-coding RNA and gene(s) among others, ultimately leading to an altered balance of key cellular functions. ...

        Research

        Ancestral SARS-CoV-2, but not Omicron, replicates less efficiently in primary pediatric nasal epithelial cells

        Children typically experience more mild symptoms of Coronavirus Disease 2019 (COVID-19) when compared to adults. There is a strong body of evidence that children are also less susceptible to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection with the ancestral viral isolate. ...

        Research

        Epigenetic dysregulation of host gene expression in Toxoplasma infection with specific reference to dopamine and amyloid pathways

        Our results provide a possible functional link between Toxoplasma gondii infection and congenital/early life and adult neurological clinical signs ...

        Research

        Does otitis media in early childhood affect later behavioural development? Results from the Western Australian Pregnancy Cohort (Raine) Study

        The relationship between early life episodes of otitis media and later behavioural development with adjustment for confounders. ...

        Research

        Experience of gastrostomy using a quality care framework: The example of rett syndrome

        Gastrostomy assisted the management of feeding difficulties and poor weight gain, and was acceptable to families ...

        Research

        The trajectories of sleep disturbances in Rett syndrome

        This paper demonstrated that the evolution of sleep problems differed between subgroups of girls and women with Rett syndrome, in part explained by age and... ...

        Research

        Medulloblastoma Down Under 2013: a report from the third annual meeting of the International Medulloblastoma Working Group

        Medulloblastoma is curable in approximately 70 % of patients. Over the past decade, progress in improving survival using conventional therapies has stalled... ...

        Research

        Content Validation of Clinician-Reported Items for a Severity Measure for CDKL5 Deficiency Disorder

        CDKL5 deficiency disorder (CDD) results in early-onset seizures and severe developmental impairments. A CDD clinical severity assessment (CCSA) was previously developed with clinician and parent-report items to capture information on a range of domains. ...

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