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        Nasal airway epithelial repair after very preterm birth

        Nasal epithelial cells from very preterm infants have a functional defect in their ability to repair beyond the first year of life, and failed repair may be associated with antenatal steroid exposure. ...

        Research

        Maternal Use of Folic Acid and Other Supplements and Risk of Childhood Brain Tumors

        Interest in a possible protective effect of maternal vitamin use before or during pregnancy against childhood brain tumors (CBT) and other childhood cancers... ...

        Research

        Linking a pharmaceutical claims database with a birth defects registry to investigate birth defect rates of suspected teratogens

        Data linkage of population administrative data is being investigated as a tool for pharmacovigilance in pregnancy in Australia. ...

        Research

        Nudging towards COVID-19 and influenza vaccination uptake in medically at-risk children: EPIC study protocol of randomised controlled trials in Australian paediatric outpatient clinics

        Children with chronic medical diseases are at an unacceptable risk of hospitalisation and death from influenza and SARS-CoV-2 infections. Over the past two decades, behavioural scientists have learnt how to design non-coercive 'nudge' interventions to encourage positive health behaviours. Our study aims to evaluate the impact of multicomponent nudge interventions on the uptake of COVID-19 and influenza vaccines in medically at-risk children. ...

        Research

        ATOMIC Ears: A Phase IIB randomised controlled trial to assess safety, tolerability and acceptability of a 5-day Dornase alfa treatment as an adjunct therapy to ventilation tube insertion for otitis media in children

        Chris Jennifer Lea-Ann Peter Ruth Brennan-Jones Kent Kirkham Richmond Thornton C J LK PC RT PhD RN PhD MBBS MRCP(UK) FRACP PhD Head, Ear Health Clinical Research Manager Co-Head, Bacterial Respiratory Infectious Disease Group; Microbiology Lead, ...

        Research

        Promoting Resilience in Stress Management for Parents (PRISM-P) intervention in parents of young children with T1D

        Keely Amy Tim Bebbington Finlay-Jones Jones KB AFJ TW MClinPsych/PhD BPsych(Hons), MPsych(Clinical), MHealthEcon, PhD (Clin Psych) MBBS DCH FRACP MD McCusker Postdoctoral Research Fellow in Type 1 Diabetes Head, Early Neurodevelopment & Mental ...

        Research

        A hospital-based asynchronous ENT telehealth service for children with otitis media: Cost-minimisation and improved access

        The purpose of this study is to explore the effectiveness of a hospital-based asynchronous ear, nose, and throat telehealth service (the Ear Portal) in reducing cost and improving access for children with otitis media. ...

        Research

        Invasive Infections Caused by Lancefield Groups C/G and A Streptococcus, Western Australia, Australia, 2000–2018

        Epidemiologic data on invasive group C/G Streptococcus (iGCGS) infections are sparse internationally. Linked population-level hospital, pathology, and death data were used to describe the disease burden in Western Australia, Australia, during 2000-2018 compared with that of invasive group A Streptococcus (GAS, Streptococcus pyogenes) infections. ...

        Research

        Topical antiseptics for chronic suppurative otitis media

        The effectiveness and safety profile of antiseptics in the treatment of chronic suppurative otitis media is uncertain ...

        Research

        The misnomer of ‘high functioning autism’: Intelligence is an imprecise predictor of functional abilities at diagnosis

        We argue that 'high functioning autism' is an inaccurate clinical descriptor when based solely on intelligence quotient demarcations ...

        Research

        The unmet clinical needs of children with developmental coordination disorder

        The aim of this study was to understand the challenges experienced by families obtaining a diagnosis and therapy for developmental coordination disorder (DCD). Parents of 435 children aged 4-18 years with persistent motor difficulties consistent with a diagnosis of DCD completed an online survey. Diagnostic timeline and diagnostic label/s received were examined, along with therapies accessed. ...

        Research

        Exploring quality of life in individuals with a severe developmental and epileptic encephalopathy, CDKL5 Deficiency Disorder

        CDKL5 Deficiency Disorder (CDD) is a rare genetic disorder caused by a mutation in the cyclin-dependent kinase-like 5 (CDKL5) gene. It is now considered to be a developmental and epileptic encephalopathy because of the early onset of seizures in association with severe global delay. Other features include cortical visual impairment, sleep and gastro-intestinal problems. Progress in clinical understanding, especially regarding the spectrum of functional ability, seizure patterns, and other comorbidities was initially slow but accelerated in 2012 with the establishment of the International CDKL5 Database (ICDD). Our aim was to use this data source to investigate quality of life (QOL) and associated factors in this disorder. ...

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