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        Rheumatic heart disease in Indigenous children in northern Australia: Differences in prevalence and the challenges of screening

        This study compared regional differences in the prevalence of rheumatic heart disease in Indigenous Australian children, and describes the logistical and... ...

        Research

        Vitamin D in fetal development: Findings from a birth cohort study

        Birth cohort studies provide an invaluable resource for studies of the influence of the fetal environment on health in later life. ...

        Research

        Impact of adolescent peer aggression on later educational and employment outcomes in an Australian cohort

        This study used prospective birth cohort data to analyse the relationship between peer aggression at 14 years of age and educational and employment outcomes... ...

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        Anxiety and Depression

        According to the Young Minds Matter study, mental health disorders such as anxiety and depression are experienced by approximately one in seven or 560,000 young people in Australia. These disorders can often have a significant impact on children’s learning and development and on family life. ...

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        Endemic country capacity building and decentralization

        Adam Punam Susan Tolu Saddler Amratia Rumisha Okitika AS PA SR TO PhD PhD PhD (Biostatistics) BSc, MPH, PMP Research Officer Honorary Research Associate Honorary Research Associate Senior Program Manager; Deputy Theme Head, Brain and Behaviour ...

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        Preparing for prevention: Assessing the community awareness of RSV and other childhood infections

        Hannah Peter Moore Richmond HC PC OAM BSc (Hons) GradDipClinEpi PhD MBBS MRCP(UK) FRACP Program Head, Infection and Vaccines Head, Vaccine Trials Group 08 6319 1427 Hannah.moore@telethonkids.org.au Program Head, Infection and Vaccines Head, Vaccine ...

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        RHD Action

        Rosemary Sophie Jonathan Wyber La Vincente Carapetis AM R SLV JR MBChB MPH FRACGP PhD BPsych (Hons) MAppEpi PhD AM MBBS FRACP FAFPHM PhD FAHMS Senior Research Fellow Rheach Deputy Director Executive Director; Head, Strep A Translation; Co-Founder of ...

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        Timing and temporal trends of influenza and pertussis vaccinations during pregnancy in three Australian jurisdictions: The Links2HealthierBubs population-based linked cohort study, 2012–2017

        Antenatal inactivated influenza and pertussis-containing vaccines offer protection against severe respiratory infections for pregnant women and infants <6 months of age. Both vaccines are recommended in pregnancy; however, little is known about temporal or jurisdictional trends and predictors of uptake. ...

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        Study protocol for controlled human infection for penicillin G against Streptococcus pyogenes: a double-blinded, placebo-controlled, randomised trial to determine the minimum concentration required to prevent experimental pharyngitis (the CHIPS trial)

        Regular intramuscular benzathine penicillin G injections have been the cornerstone of rheumatic heart disease (RHD) secondary prophylaxis since the 1950s. As the pharmacological correlate of protection remains unknown, it is difficult to recommend changes to this established regimen. Determining the minimum effective penicillin exposure required to prevent Streptococcus pyogenes infection will accelerate development of new long-acting penicillins for RHD prevention as well as inform opportunities to improve existing regimens. The CHIPS trial will address this knowledge gap by directly testing protection afforded by different steady state plasma concentrations of penicillin in an established model of experimental human S. pyogenes pharyngitis. ...

        Research

        Qualitative assessment of healthy volunteer experience receiving subcutaneous infusions of high-dose benzathine penicillin G (SCIP) provides insights into design of late phase clinical studies

        Secondary prophylaxis to prevent rheumatic heart disease (RHD) progression, in the form of four-weekly intramuscular benzathine benzylpenicillin G (BPG) injections, has remained unchanged since 1955. Qualitative investigations into patient preference have highlighted the need for long-acting penicillins to be delivered less frequently, ideally with reduced pain. ...

        Research

        Perinatal Women’s Perspectives of, and Engagement in, Digital Emotional Well-Being Training: Mixed Methods Study

        Psychological distress in the early postpartum period can have long-lasting deleterious effects on a mother's well-being and negatively affect her infant's development. Intervention approaches based in contemplative practices such as mindfulness and loving-kindness and compassion are intended to alleviate distress and cultivate well-being and can be delivered effectively as digital mental health interventions. ...

        Research

        Infant Whole-Cell Versus Acellular Pertussis Vaccination in 1997 to 1999 and Risk of Childhood Hospitalization for Food-Induced Anaphylaxis: Linked Administrative Databases Cohort Study

        Evidence suggests that children who had received an initial priming dose of whole-cell pertussis (wP) vaccine, rather than acellular pertussis (aP) vaccine, had a lower risk of developing IgE-mediated food allergy, the most common cause of anaphylaxis-related hospital presentations of childhood. ...

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