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        FastMix: a versatile data integration pipeline for cell type-specific biomarker inference

        Flow cytometry (FCM) and transcription profiling are the two widely used assays in translational immunology research. However, there is no data integration pipeline for analyzing these two types of assays together with experiment variables for biomarker inference. ...

        Research

        Getting to the heart of the matter: a research partnership with Aboriginal women in South and Central Australia

        Within the vast majority of qualitative health research involving Indigenous populations, Indigenous people have been marginalised from research conceptualisation and conduct. This reflects a lack of regard for Indigenous ways of knowing, being, and doing, has served to perpetuate deficit narratives of Indigenous peoples’ health and wellbeing, and contributes to failure in addressing inequities as a result of ongoing colonisation and institutionalised oppression and racism. ...

        Research

        The bone marrow microenvironment of pre-B acute lymphoblastic leukemia at single-cell resolution

        The bone marrow microenvironment plays a key role in leukemia progression, but its molecular complexity in pre-B cell acute lymphoblastic leukemia (B-ALL), the most common cancer in children, remains poorly understood. To gain further insight, we used single-cell RNA sequencing to characterize the kinetics of the murine BMM during B-ALL progression. ...

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        Tonsils at Telethon: developing a standardised collection of tonsil photographs for group A streptococcal (GAS) research

        Group A streptococcus (GAS) infections, such as pharyngitis and impetigo, can lead to rheumatic fever and rheumatic heart disease (RHD). Australian Aboriginal and Torres Strait Islander populations experience high rates of RHD and GAS skin infection, yet rates of GAS pharyngitis are unclear.  ...

        Research

        Neonatal high frequency ventilation: Current trends and future directions

        High frequency ventilation (HFV) in neonates has been in use for over forty years. Some early HFV ventilators are no longer available, but high frequency oscillatory ventilation (HFOV) and jet ventilators (HFJV) continue to be commonly employed. Advanced HFOV models available outside of the United States are much quieter and easier to use, and are available as options on many conventional ventilators, providing important improvements such as tidal volume measurement and targeting. ...

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        2023 Australian guideline for assessing and managing cardiovascular disease risk

        The 2023 Australian guideline for assessing and managing cardiovascular disease risk provides updated evidence-based recommendations for the clinical assessment and management of cardiovascular disease (CVD) risk for primary prevention. It includes the new Australian CVD risk calculator based on an equation developed from a large New Zealand cohort study, customised and recalibrated for the Australian population. The new guideline replaces the 2012 guideline that recommended CVD risk assessment using the Framingham risk equation.  ...

        Research

        Barriers and facilitators to mental health treatment access and engagement for LGBTQA+ people with psychosis: a scoping review protocol

        The prevalence of psychosis has been shown to be disproportionately high amongst sexual and gender minority individuals. However, there is currently little consideration of the unique needs of this population in mental health treatment, with LGBTQA+ individuals facing barriers in accessing timely and non-stigmatising support for psychotic experiences.  ...

        Research

        Impact of Cardiovascular Imaging Results on Medication Use and Adherence: A Systematic Review and Meta-Analysis

        Cardiovascular imaging results offer valuable information that can guide health decisions, but their impact on medication use and adherence is unclear. This systematic review and meta-analysis aimed to determine the downstream impact of cardiovascular imaging results on medication use and adherence. ...

        Research

        Lung structural and functional impairments in young children with cystic fibrosis diagnosed following newborn screening – A nationwide observational study

        Non-invasive and sensitive clinical endpoints are needed to monitor onset and progression of early lung disease in children with cystic fibrosis (CF). We compared lung clearance index (LCI), FEV1, functional and structural lung magnetic resonance imaging (MRI) outcomes in Swiss children with CF diagnosed following newborn screening.  ...

        Research

        Ngulluk Koolunga Ngulluk Koort (Our Children, Our Heart) Program

        Brad Carol Glenn Carrington Steve Farrant Michie Pearson Shepherd Zubrick Related Projects Elder Researchers Contact BM C G CCJ SR If you would like more information or to become involved in the project, please get in touch with : Carol Michie T: ( ...

        Research

        Topical antibiotics with steroids for chronic suppurative otitis media

        To assess the effects of adding a topical steroid to topical antibiotics in the treatment of people with chronic suppurative otitis media ...

        Research

        Paediatric antimicrobial stewardship and safe prescribing: An assessment of medical staff knowledge and behaviour

        Participants demonstrated a good understanding of safe prescribing and antimicrobial stewardship ...

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