A large proportion of preschoolers do not meet the recommended three hours of daily physical activity. A potential source of daily physical activity could be that provided via the family dog. This qualitative study aimed to explore the barriers and motivators to preschoolers playing with their dog and participating in family dog walks. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• March 2021

The aim of our investigation was to assess the chemical composition of a range of e-liquids available in Australia, focusing on nicotine and other potentially harmful compounds ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• February 2019

This multinational study presents unique body mass index z score trajectories in youth with type 1 diabetes across three continents ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• February 2020

Overweight and obesity in children continues to increase. Yet, the role of active transport, namely walking, in mitigating these trends remains unclear. This study examined the cross-sectional association between walkability and children's Body Mass Index (BMI) and how this varies by socio-economic and lifestyle characteristics. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• September 2024

The structures and functions of organelles in cells depend on each other but have not been systematically explored. We established stable knockout cell lines of peroxisomal, Golgi and endoplasmic reticulum genes identified in a whole-genome CRISPR knockout screen for inducers of mitochondrial biogenesis stress, showing that defects in peroxisome, Golgi and endoplasmic reticulum metabolism disrupt mitochondrial structure and function.  ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• January 2024

Tick-borne diseases are a growing global health concern. Despite extensive studies, ill-defined tick-associated pathologies remain with unknown aetiologies. Human immunological responses after tick bite, and inter-individual variations of immune-response phenotypes, are not well characterised. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• November 2022

Vaccines have generally been developed with limited insight into their molecular impact. While systems vaccinology enables characterization of mechanisms of action, these tools have yet to be applied to infants, who are at high risk of infection and receive the most vaccines. Bacille Calmette-Guérin (BCG) protects infants against disseminated tuberculosis (TB) and TB-unrelated infections via incompletely understood mechanisms. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• May 2022

We report an overall good adherence to ACE inhibitors and statins during a clinical trial, although there was a clear decline in adherence over time ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• May 2020

Our objective was to examine influenza vaccine safety in Australian children aged under 10 years in 2013. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• November 2014

In adolescents with type 1 diabetes, the group with the highest tertile of albumin excretion showed more evidence of early renal and CV disease ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• November 2014

In adults, the unpredictability of voriconazole pharmacokinetics, particularly in those patients receiving chemotherapy, is well recognised. A paucity of... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• July 2012

Exposure to diesel exhaust particles (DEP) is thought to exacerbate many pre-existing respiratory diseases. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• September 2012