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        Validation of a mouse xenograft model system for gene expression analysis of human acute lymphoblastic leukaemia

        Pre-clinical models that effectively recapitulate human disease are critical for expanding our knowledge of cancer biology and drug resistance mechanisms. ...

        Research

        Validation of Physical Activity Assessment in Type 1 Diabetes – an Essential Step to Incorporating Systematic Measurement of Activity as the Standard of Care in Youth

        Liz Tim Davis Jones EA TW MBBS FRACP PhD MBBS DCH FRACP MD Head, Chronic & Severe Diseases Research Focus Area; Clinical Lead, Diabetes and Obesity Research Co-head, Diabetes and Obesity Research Head, Chronic & Severe Diseases Research Focus Area; ...

        Research

        Are low sun exposure and/or Vitamin D risk factors for type 1 diabetes

        Evidence supports that higher sun exposure and/or vitamin D sufficiency in pregnancy, or supplementation in early life, decreases type 1 diabetes risk ...

        Research

        Use of linked administrative and laboratory data to confirm that serum 25(OH)D levels in pregnant women can be predicted from satellite estimates of ultraviolet radiation

        Serum 25 hydroxyvitamin D [25(OH)D] levels of pregnant women have been linked to various health outcomes in their offspring. Satellite-derived ultraviolet radiation (UVR) data have been used as a proxy for 25(OH)D levels, as individual-level cohort studies are time-consuming, costly and only feasible for common outcomes. ...

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        Developing new models of mitochondrial diseases using CRISPR/Cas technologies

        Aleksandra Filipovska AF BSc PhD Louis Landau Chair in Child Health Research; NHMRC Leadership Fellow; Deputy Director, ARC Centre of Excellence for Synthetic Biology; Adjunct Research Professor, Monash University Louis Landau Chair in Child Health ...

        Research

        Vitamin D supplementation, moderate sun exposure, and control of immune diseases

        There is considerable debate about the benefits of vitamin D supplementation for multiple sclerosis, allergic asthma, and type 1 diabetes. ...

        Research

        The stark reality of rheumatic heart disease

        This editorial refers to ‘Characteristics, complications, and gaps in evidence-based interventions in rheumatic heart disease: the Global Rheumatic Heart... ...

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        Cellular and molecular mechanisms of vitamin D in food allergy

        Epidemiological evidence from the past decade suggests a role of vitamin D in food allergy pathogenesis ...

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        PGE2 pulsing of murine bone marrow cells reduces migration of daughter monocytes/macrophages in vitro and in vivo

        Our results reveal long-lasting changes to progenitor cells of monocytes/macrophages by a 2-hour dimethyl PGE2 pulse that, in turn, limits the migration of their daughter cells to chemoattractants and inflammatory mediators. ...

        Research

        Maternal, umbilical cord and neonatal inflammatory and hematologic markers in histologic chorioamnionitis

        Maternal, umbilical cord, neonatal inflammatory, hematologic markers, histologic chorioamnionitis... ...

        Research

        More Than Effects in Skin: Ultraviolet Radiation-Induced Changes in Immune Cells in Human Blood

        Cells of the skin and circulation are in constant two-way communication. Following exposure of humans to sunlight or to phototherapy, there are alterations in the number, phenotype and function of circulating blood cells. ...

        Research

        Trends in alcohol-related injury admissions in adolescents in Western Australia and England: Population-based cohort study

        More needs to be done to address alcohol-related harm, and on-going monitoring is required to assess the effectiveness of strategies. ...

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