Epigenetic modifications are associated with hepatic fat accumulation and non-alcoholic fatty liver disease (NAFLD). However, few epigenetic modifications directly implicated in such processes have been identified during adolescence, a critical developmental window where physiological changes could influence future disease trajectory. To investigate the association between DNA methylation and NAFLD in adolescence, we undertook discovery and validation of novel methylation marks, alongside replication of previously reported marks. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• February 2023

Preterm birth is the leading cause of perinatal morbidity and mortality and is associated with adverse developmental and long-term health outcomes, including several cardiometabolic risk factors and outcomes. However, evidence about the association of preterm birth with later body size derives mainly from studies using birth weight as a proxy of prematurity rather than an actual length of gestation. We investigated the association of gestational age (GA) at birth with body size from infancy through adolescence. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• January 2023

DNA methylation has been shown to be associated with adiposity in adulthood. However, whether similar DNA methylation patterns are associated with childhood and adolescent body mass index (BMI) is largely unknown. More insight into this relationship at younger ages may have implications for future prevention of obesity and its related traits. We examined whether DNA methylation in cord blood and whole blood in childhood and adolescence was associated with BMI in the age range from 2 to 18 years using both cross-sectional and longitudinal models. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• November 2020

In vitro investigations of human innate immune responses to extracellular bacteria commonly utilise killed preparations in preference to live... ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• August 2011

Rett syndrome is a severe neurodevelopmental disorder that typically affects females. Little is known about the natural history and survival time of these femal ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2010
• October 2010

We aimed to describe birth prevalence of rare craniofacial anomalies and associations with antenatal and perinatal factors. All live and stillbirths in Western Australia between 1980 and 2010 were identified from the Western Australian Birth Registrations and the Midwives Notification System (also provides information on antenatal and perinatal factors). ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• October 2021

This study assessed the potential bias present in a sample of actively consented students, and in the estimates of associations between variables obtained... ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• March 2014

There is increasing evidence that the functional state of the immune system at birth is predictive of the kinetics of immune maturation in early infancy. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2010
• April 2010

Anti-viral innate immune responses may be impaired in asthma, although the mechanisms are not well understood. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2010
• January 2010

This study reports on a three-year group randomized controlled trial, the Cyber Friendly Schools Project, aimed to reduce cyberbullying among grade 8 students ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• November 2018

This study reports on a three-year group randomized controlled trial, the Cyber Friendly Schools Project (CFSP), aimed to reduce cyberbullying among grade 8... ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• March 2015

We report osteomyelitis incidence in indigenous children of northern Australia is amongst the highest reported in the world ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• February 2016