T-cell activation induces context-specific gene expression programs that promote energy generation and biosynthesis, progression through the cell cycle and ultimately cell differentiation. The aim of this study was to apply the omni ATAC-seq method to characterize the landscape of chromatin changes induced by T-cell activation in mature naïve CD4+ T-cells. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• July 2021

These data suggest that altered methylation of CpG loci within SLC6A4 may provide a robust marker of adiposity across the life course ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• May 2019

Three Pseudomonas sp. strains isolated from marine sponges have shown potential quorum sensing inhibition activity ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• May 2020

Review of the viral sensing pathways and organizing principles that govern the innate immune response to infection ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• November 2016

Mononuclear phagocyte population is directly involved in the production of proinflammatory chemokines that attract other immune cells ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• February 2016

We report a role for the mitochondrial single-stranded DNA binding protein (mtSSB) in regulating mitochondrial DNA (mtDNA) replication initiation in mammalian mitochondria. Transcription from the light-strand promoter (LSP) is required both for gene expression and for generating the RNA primers needed for initiation of mtDNA synthesis. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• July 2021

QuantSeq, coupled with a fast quantification method such as Salmon, should provide a viable alternative to traditional RNA-Seq in many applications ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• December 2019

Investigators: Peter Le Souef Project description There have been almost no studies of the first illness caused by HIV infection. We have recruited adults from Mozambique who have presented to hospital with a febrile illness and determined which ...

• 1. Telethon Kids Institute
• Projects

Clinical management of breast cancer (BC) metastasis remains an unmet need as it accounts for 90% of BC-associated mortality. Although the luminal subtype, which represents >70% of BC cases, is generally associated with a favorable outcome, it is susceptible to metastatic relapse as late as 15 years after treatment discontinuation. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• May 2023

VEGFR-3 signaling plays a central role in lymphatic biology, both in the development of the lymphatic network during embryogenesis as well as in... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• November 2015

This study describes the development and molecular characterization of a panel of patient-derived infant leukemia oncogene xenografts and their sensitivity... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• January 2015

The analysis of CAGE (Cap Analysis of Gene Expression) time-courses has been applied to examine the dynamics of enhancer and promoter by sequentially... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• July 2015