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        97-108 of 305 results for 'endgame '

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        Caring for Pregnant Women with Rheumatic Heart Disease: A Qualitative Study of Health Service Provider Perspectives

        Rheumatic heart disease (RHD) persists in low-middle-income countries and in high-income countries where there are health inequities. RHD in pregnancy (RHD-P) is associated with poorer maternal and perinatal outcomes. Our study examines models of care for women with RHD-P from the perspectives of health care providers. ...

        Research

        High risk of early sub-therapeutic penicillin concentrations after intramuscular benzathine penicillin G injections in Ethiopian children and adults with rheumatic heart disease

        Intramuscular benzathine penicillin G (BPG) injections are a cornerstone of secondary prophylaxis to prevent acute rheumatic fever (ARF) and rheumatic heart disease (RHD). Uncertainties regarding inter-ethnic and preparation variability, and target exposure profiles of BPG injection are key knowledge gaps for RHD control. ...

        Research

        The Path to Group A Streptococcus Vaccines: World Health Organization Research and Development Technology Roadmap and Preferred Product Characteristics

        Here, the role, status, and directions in Group A Streptococcus vaccines research are discussed ...

        Research

        Atlas of group A streptococcal vaccine candidates compiled using large-scale comparative genomics

        We identified the existence of more than 290 clinically associated genomic phylogroups across 22 countries, highlighting challenges in designing vaccines of global utility ...

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        Are minor echocardiographic changes associated with an increased risk of acute rheumatic fever or progression to rheumatic heart disease?

        We aimed to determine the significance of minor heart valve abnormalities, including Borderline RHD, in predicting the future risk of acute rheumatic fever. ...

        Research

        The prevention, diagnosis and management of central venous line infections in children

        With advancing paediatric healthcare, the use of central venous lines has become a fundamental part of management of neonates and children. ...

        Research

        Acceptability of sonicated versus unsonicated reconstituted (powdered) benzathine penicillin G for rheumatic fever prophylaxis

        Jonathan Carapetis AM JR AM MBBS FRACP FAFPHM PhD FAHMS Executive Director; Head, Strep A Translation; Co-Founder of REACH 08 6319 1000 contact@telethonkids.org.au Institute Director; Head, Strep A Translation; Co-Founder of REACH Professor ...

        Research

        Secondary Antibiotic Prophylaxis for Latent Rheumatic Heart Disease

        Rheumatic heart disease affects more than 40.5 million people worldwide and results in 306,000 deaths annually. Echocardiographic screening detects rheumatic heart disease at an early, latent stage. Whether secondary antibiotic prophylaxis is effective in preventing progression of latent rheumatic heart disease is unknown. ...

        Research

        The global epidemiology of impetigo: A systematic review of the population prevalence of impetigo and pyoderma

        We conducted a comprehensive, systematic review of the global childhood population prevalence of impetigo and the broader condition pyoderma. ...

        Research

        Changes in the clinical and epidemiological features of group A streptococcal bacteraemia in Australia's northern territory

        We aimed to measure the incidence and severity of invasive Group A Strep disease in the NT since 1996. ...

        Research

        Utility of auscultatory screening for detecting rheumatic heart disease in high-risk children in Australia's Northern Territory

        Sensitivity and positive predictive value of cardiac auscultation compared with echocardiography is poor, regardless of the expertise of the auscultator. ...

        Research

        Strep A Vaccine Global Consortium (SAVAC)

        Jonathan Carapetis AM JR AM MBBS FRACP FAFPHM PhD FAHMS Executive Director; Head, Strep A Translation; Co-Founder of REACH 08 6319 1000 contact@telethonkids.org.au Institute Director; Head, Strep A Translation; Co-Founder of REACH Professor ...

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