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        Prediction of asthma in childhood from wheezing phenotypes up to age 3 years: findings from community cohorts in Western Australian and the United Kingdom

        Pat Holt PG PhD, DSc, FRCPath, FRCPI, FAA Emeritus Honorary Researcher Patrick.Holt@telethonkids.org.au Emeritus Honorary Researcher Prof Holt established the Division of Cell Biology at the Institute's inception in 1990, with his research group's ...

        Research

        Examining relationships between vitamin D over the first decade of life and development of asthma and allergy

        Pat Prue Holt Hart PG PH PhD, DSc, FRCPath, FRCPI, FAA BSc (Hons) MSc PhD Emeritus Honorary Researcher Head, Inflammation Patrick.Holt@telethonkids.org.au prue.hart@telethonkids.org.au Emeritus Honorary Researcher Head, Inflammation Prof Holt ...

        Research

        Developmental-associated dysregulation of innate anti-microbial immunity in early life as a determinant of susceptibility to atopic asthma

        Pat Holt PG PhD, DSc, FRCPath, FRCPI, FAA Emeritus Honorary Researcher Patrick.Holt@telethonkids.org.au Emeritus Honorary Researcher Prof Holt established the Division of Cell Biology at the Institute's inception in 1990, with his research group's ...

        Research

        Basophil counts in PBMC populations during childhood acute wheeze/asthma are associated with future exacerbations

        Our findings suggest that the proportion of degranulated basophils can also be associated with recurrent exacerbations ...

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        A marked shift in innate and adaptive immune response in chinese immigrants living in a western environment

        There is a marked shift in innate and adaptive immune responses in Chinese immigrants after living in a Western environment for several years ...

        Research

        Persistent and compartmentalised disruption of dendritic cell subpopulations in the lung following influenza A virus infection

        Immunological homeostasis in the respiratory tract is thought to require balanced interactions between networks of dendritic cell (DC) subsets in lung... ...

        Research

        Anti-infective proteins in breast milk and asthma-associated phenotypes during early childhood

        The impact of breast milk feeding on susceptibility to asthma in childhood is highly controversial, due in part to failure of the majority of studies in the... ...

        Research

        Serum 25-hydroxyvitamin D concentrations and cardiometabolic risk factors in adolescents and young adults

        Associations between serum 25(OH)D concentrations and cardiometabolic risk factors from adolescence to young adulthood in the Raine Study ...

        Research

        The WHF Roadmap for Reducing CV Morbidity and Mortality Through Prevention and Control of Rheumatic Heart Disease

        As a general guide, the Roadmap is meant to serve as the foundation for the development of tailored plans of action to improve RHD control in specific contexts. ...

        Research

        Low serum 25-hydroxyvitamin D concentrations associate with non-alcoholic fatty liver disease in adolescents independent of adiposity

        This paper examined the link between low serum Vitamin D levels and development of non-alcoholic fatty liver disease (NAFLD) in adolescents between 14 and 17... ...

        Research

        Functional differences in airway dendritic cells determine susceptibility to IgE-sensitization

        Respiratory IgE-sensitization to innocuous antigens increases the risk for developing diseases such as allergic asthma. ...

        Research

        CFTR-dependent defect in alternatively-activated macrophages in cystic fibrosis

        CFTR-dependent imbalance of macrophage phenotypes and functions could contribute to the exaggerated inflammatory response seen in CF lung disease ...

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