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        Epigenome-wide meta-analysis of DNA methylation and childhood asthma

        Novel loci differentially methylated in newborns represent potential biomarkers of risk of asthma by school age ...

        Research

        Upper Airway Cell Transcriptomics Identify a Major New Immunological Phenotype with Strong Clinical Correlates in Young Children with Acute Wheezing

        Asthma exacerbations in children can be divided into IRF7hi versus IRF7lo phenotypes with associated differences in clinical phenotypes ...

        Research

        Prenatal adverse life events increase the risk for atopic diseases in children, which is enhanced in the absence of a maternal atopic predisposition

        There is evidence to suggest an association between prenatal maternal stress and the development of asthma or other atopic diseases in offspring. ...

        Research

        After asthma: Redefining airways diseases

        Identify entrenched areas of asthma management and treatment in which progress has stalled and to challenge current principles ...

        Research

        Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype

        Previous analyses of family data from the Tasmanian Longitudinal Health Study provide evidence that this phenotype has a stronger genetic cause than asthma... ...

        Research

        Hierarchy and molecular properties of house dust mite allergens

        The allergenic load of house dust mite allergy is largely constituted by a few proteins with a hierarchical pattern of allergenicity. ...

        Research

        Children with East Asian-Born Parents Have an Increased Risk of Allergy but May Not Have More Asthma in Early Childhood

        Children of East Asian ancestry born in Australia have a higher burden of most allergic diseases in the first 6 years of life, whereas asthma may follow a different pattern ...

        Research

        High fractional exhaled nitric oxide and sputum eosinophils are associated with an increased risk of future virus-induced exacerbations: A prospective cohort study.

        High fractional exhaled nitric oxide and sputum eosinophils are associated with an increased risk of future virus-induced exacerbations. ...

        Research

        Rhinovirus-induced asthma exacerbations and risk populations

        Asthma exacerbations are heterogeneous conditions that involve the complex interplay between environmental exposures and innate and adaptive immune function ...

        Research

        Vitamin D 3 deficiency enhances allergen-induced lymphocyte responses in a mouse model of allergic airway disease

        In this study, using a mouse model, we determined whether vitamin D deficiency in utero and during early life modulated the severity of asthma. ...

        Research

        Viral infections and atopy in asthma pathogenesis: New rationales for asthma prevention and treatment

        Prospective birth cohort studies tracking asthma initiation and consolidation in community cohorts have identified viral infections occurring against a... ...

        Research

        Prophylactic use of sublingual allergen immunotherapy in high-risk children: A pilot study

        These findings suggest that this modified version of SLIT should be considered for retesting of mucosal-based immunotherapy for atopic asthma prevention. ...

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