Childhood is a critical period of immune development. During this time, naïve CD4 T cells undergo programmed cell differentiation, mediated by epigenetic changes, in response to external stimuli leading to a baseline homeostatic state that may determine lifelong disease risk. However, the ontogeny of epigenetic signatures associated with CD4 T cell activation during key developmental periods are yet to be described. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• February 2023

Increased maternal egg ingestion is associated with increased breastmilk ovalbumin, and markers of immune tolerance in infants ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• December 2016

We aimed to determine whether regular consumption of egg protein from 4-6 month old reduced the risk of IgE-mediated egg allergy in infants without eczema. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• May 2017

Vitamin D status in early life has been linked to the risk of allergic disease in multiple observational studies. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• January 2014

Jonathan Glenn Katharine Rosemary Tom Carapetis AM Pearson Noonan Wyber Snelling JR G KN R T AM MBBS FRACP FAFPHM PhD FAHMS BA (Education) PhD Candidate MBBS (Hons) MSc MBChB MPH FRACGP PhD BMBS DTMH GDipClinEpid PhD FRACP Executive Director; Head, ...

• 1. Telethon Kids Institute
• Projects

Conflicting findings regarding the level of protection offered by seasonal influenza vaccination against pandemic influenza H1N1 have been reported. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• August 2011

In our study, we aimed to examine early infant feeding and adiposity risk in a longitudinal cohort from birth to young adulthood using new as well as... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• October 2014

Building data linkage capabilities, and how linked databases can be used to identify persons with IDD and used for population-based research ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• October 2019

There was a significant improvement in the management of anaphylaxis after the introduction of intensified physician training programs ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• September 2018

We conducted an investigation of all cases coded as anaphylaxis presenting to the main tertiary PED in Perth, Australia, where all coding is performed by staff. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• May 2017

We have undertaken to validating the specificity of commercially available antibodies marketed for flow cytometry to measure PKCα, βI, βII, δ, ε, η, θ, ζ, ι/λ and μ ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• June 2019

There is no consensus about which outcomes should be evaluated in studies of pulmonary exacerbations in people with cystic fibrosis (CF). Outcomes used for evaluation should be meaningful; that is, they should capture how people feel, function or survive and be acknowledged as important to people with CF, or should be reliable surrogates of those outcomes. We aimed to summarise the outcomes and corresponding endpoints which have been reported in studies of pulmonary exacerbations, and to identify those which are most likely to be meaningful. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• November 2020