Helen Jenny Peter Leonard Downs Richmond HM JA PC MBChB MPH BApplSci (physio) MSc PhD MBBS MRCP(UK) FRACP Principal Research Fellow Program Head, Development and Disability Head, Vaccine Trials Group +61 419 956 946 08 6319 1763 helen.leonard@ ...

• 1. Telethon Kids Institute
• Projects

This manuscript will give a brief overview of clinical trial design including the strengths and limitations of various approaches ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• November 2019

Helen Jenny Peter Leonard Downs Jacoby HM JA PJ MBChB MPH BApplSci (physio) MSc PhD BA (Hons) MSc Principal Research Fellow Program Head, Development and Disability Biostatistician +61 419 956 946 08 6319 1763 helen.leonard@telethonkids.org.au ...

• 1. Telethon Kids Institute
• Projects

Accumulating evidence indicates that an early, robust type 1 interferon (IFN) response to SARS-CoV-2 is important in determining COVID-19 outcomes, with an inadequate IFN response associated with disease severity. Our objective was to examine the prophylactic potential of IFN administration to limit viral transmission. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• July 2023

Prioritisation of clinical trials ensures that the research conducted meets the needs of stakeholders, makes the best use of resources and avoids duplication. The aim of this review was to identify and critically appraise approaches to research prioritisation applicable to clinical trials, to inform best practice guidelines for clinical trial networks and funders. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• December 2022

We hypothesised that scheduling an additional (third) dose of oral human rotavirus vaccine for children aged 6 to <12 months would improve protection ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• November 2019

This study provides a basis for further studies to determine if there are any benefits of the therapeutic effects of narrowband UVB radiation on MS progression ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• April 2018

Rett syndrome is associated with severe functional impairments and many comorbidities, each in urgent need of treatments. Mutations in the MECP2 gene were identified as causing Rett syndrome in 1999. Over the past 20 years there has been an abundance of preclinical research with some studies leading to human clinical trials. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• March 2022

Continuous glucose monitoring adherence and patterns of use are individualized ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• May 2016

Acute respiratory infections (ARI) are the most common cause of paediatric hospitalisation. There is an urgent need to address ongoing critical knowledge gaps in ARI management. The Pragmatic Adaptive Trial for Respiratory Infections in Children (PATRIC) Clinical Registry will evaluate current treatments and outcomes for ARI in a variety of paediatric patient groups. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• January 2024

The monovalent acellular pertussis vaccine is immunogenic and safe in neonates ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• November 2018

Andrew Matt Whitehouse Watch and listen to Andrew Cooper AJ MC PhD BCA Marketing, BSc Statistics and Applied Statistics, PhD Angela Wright Bennett Professor of Autism Research at Telethon Kids and University of Western Australia; Director, CliniKids ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• December 2021