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        FeBRILe3– Fever, Blood cultures and Readiness for discharge in Infants Less than 3 months’ old

        Tom Snelling T BMBS DTMH GDipClinEpid PhD FRACP Head, Infectious Disease Implementation Research 08 6319 1817 tom.snelling@telethonkids.org.au Head, Infectious Disease Implementation Research Professor Tom Snelling is Head of the Infectious Disease ...

        Research

        Safety and Tolerability of V114 Pneumococcal Vaccine in Infants: A Phase 3 Study

        Disease caused by Streptococcus pneumoniae is associated with considerable morbidity and mortality in children. Pneumococcal conjugate vaccines are well tolerated and effective at reducing pneumococcal disease caused by vaccine serotypes. VAXNEUVANCE (V114) is a 15-valent PCV containing 13 serotypes in Prevnar 13, plus serotypes 22F and 33F. This large phase 3 study evaluated safety and tolerability of V114 in infants.  ...

        Research

        Predictors of hospital readmission in infants less than 3 months old

        To examine rates and predictors of 7-day readmission in infants hospitalised before 3 months of age with infectious and non-infectious conditions. A retrospective population-based data-linkage study of 121 854 infants from a 5-year metropolitan birth cohort (2008-2012). Cox proportional hazard models were used to examine associations between infant and maternal factors with 7-day readmission. ...

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        Phase 3 Trial of Epicutaneous Immunotherapy in Toddlers with Peanut Allergy

        No approved treatment for peanut allergy exists for children younger than 4 years of age, and the efficacy and safety of epicutaneous immunotherapy with a peanut patch in toddlers with peanut allergy are unknown. ...

        Research

        Overall efficacy of HPV-16/18 AS04-adjuvanted vaccine against grade 3 or greater cervical intraepithelial neoplasia

        We report vaccine efficacy against CIN3+ and adenocarcinoma in situ (AIS) in the end-of-study analysis of PApilloma TRIal against Cancer In young Adults. ...

        Research

        Suicide prevention for Aboriginal and Torres Strait Islander young people: Fact Sheet 3

        This is the third fact sheet regarding the Aboriginal and Torres Strait Islander Suicide Prevention Evaluation Project. ...

        Research

        EEG power at 3 months in infants at high familial risk for autism

        Reduced frontal power at 3 months may indicate increased risk for reduced expressive language skills at 12 months. ...

        Research

        Effectiveness of a 3 + 0 pneumococcal conjugate vaccine schedule against invasive pneumococcal disease among a birth cohort of 1.4 million children in Australia

        Our population-based cohort study demonstrates that >90% coverage in the first year of a universal 3 + 0 PCV program provided high population-level protection ...

        Research

        Developmental regulation of type 1 and type 3 interferon production and risk for infant infections and asthma development

        Type 1 and 3 interferon response capacity appears strongly developmentally constrained at birth ...

        Research

        Severe hypoglycemia rates are not associated with HbA1c: A cross-sectional analysis of 3 contemporary pediatric diabetes registry databases

        To examine the association between glycated hemoglobin (HbA1c) and severe hypoglycemia rates in patients with type 1 diabetes receiving usual care. ...

        Research

        Vitamin D 3 deficiency enhances allergen-induced lymphocyte responses in a mouse model of allergic airway disease

        In this study, using a mouse model, we determined whether vitamin D deficiency in utero and during early life modulated the severity of asthma. ...

        Research

        Protocol of DREAM3R: DuRvalumab with chEmotherapy as first-line treAtment in advanced pleural Mesothelioma-a phase 3 randomised trial

        There is a strong theoretical rationale for combining checkpoint blockade with cytotoxic chemotherapy in pleural mesothelioma and other cancers. ...

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