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        Research

        The role of PKCzeta in cord blood T-cell maturation towards Th1 cytokine profile and its epigenetic regulation by fish oil

        Here, we present evidence that there are two major control points to explain the immunodeficiency in CB T-cells, leading to a decreased IFNy synthesis. ...

        Research

        Childhood pneumonia and meningitis in the Eastern Highlands Province, Papua New Guinea in the era of conjugate vaccines: study methods and challenges

        Recruitment of large numbers of pediatric pneumonia and meningitis cases and community controls in a third-world setting presents unique challenges ...

        Research

        Analysis of the human monocyte-derived macrophage transcriptome and response to lipopolysaccharide provides new insights into genetic aetiology of inflammatory bowel disease.

        We propose that this system provides a model for the differentiation and adaptation of monocytes entering the intestinal lamina propria. ...

        Research

        Otitis-prone children produce functional antibodies to pneumolysin and pneumococcal polysaccharides

        The production of functional antipneumococcal antibodies in otitisprone children demonstrates that they respond to the current pneumococcal conjugate vaccine (PCV)and are likely to respond to pneumolysin-based vaccines as effectively as healthy children. ...

        Research

        Induced sputum to detect lung pathogens in young children with cystic fibrosis

        we aimed to determine the sensitivity and specificity of induced sputum with and without airway clearance techniques to detect lower airway pathogens in kids. ...

        Research

        Vitamin D over the first decade and susceptibility to childhood allergy and asthma

        We aimed to research relationships between 25(OH)D levels from birth to 10 y/o and susceptibility to allergic sensitization, respiratory issues and asthma. ...

        Research

        Protective benefit of predominant breastfeeding against otitis media may be limited to early childhood: results from a prospective birth cohort study

        Our findings are in line with a number of epidemiological studies which show a positive association between breastfeeding and OM in early childhood ...

        Research

        Characteristics associated with clinical severity and inflammatory phenotype of naturally occurring virus-induced exacerbations of asthma in adults

        Type 2 inflammation is present in patients during virus-induced asthma exacerbations, to the same degree as non-viral exacerbations ...

        Research

        Distress and psychological morbidity do not reduce over time in carers of patients with high-grade glioma

        his study aimed to determine how carer distress and psychological morbidity change over time following a patient's diagnosis of high-grade glioma ...

        Research

        Influence of maternal obesity on the long-term health of offspring

        Including immediate implications for pregnancy complications, increasing evidence implicates maternal obesity having a major impact on long term child health. ...

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