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        Research

        Targeting cytokine- and therapy-induced PIM1 activation in preclinical models of T-cell acute lymphoblastic leukemia and lymphoma

        IL7 and glucocorticoids coordinately drive aberrant activation of PIM1 and suggests that T-ALL and T-LBL patients could benefit from PIM inhibition ...

        Research

        The development of a consensus statement for the prescription of powered wheelchair standing devices in Duchenne muscular dystrophy

        PURPOSE: To develop a consensus statement for the prescription of a Powered Wheelchair Standing Device (PWSD) in young people with Duchenne muscular dystrophy (DMD). MATERIALS AND METHODS: An international multidisciplinary panel comprising clinicians and users (young people with DMD) along with their parents was consulted. A literature review was undertaken and a Delphi method was utilised to generate consensus statements. ...

        Research

        Germline Elongator mutations in Sonic Hedgehog medulloblastoma

        Genetic predisposition to proteome instability may be a determinant in the pathogenesis of paediatric brain cancers ...

        Research

        The detection of bile acids in the lungs of paediatric cystic fibrosis patients is associated with altered inflammatory patterns

        Our work has identified a clinically relevant host-derived factor that may participate in shaping early events in the aetiology of CF respiratory disease ...

        Research

        Rheumatic heart disease in pregnancy: Profile of women admitted to a Western Australian tertiary obstetric hospital

        This retrospective study assessed maternal and perinatal outcomes for women with rheumatic heart disease admitted to the largest tertiary obstetric hospital ...

        Research

        Vitamin D receptor polymorphisms are associated with severity of wheezing illnesses and asthma exacerbations in children

        These findings suggest that genetic variants at the VDR locus may play a role in acute wheeze/asthma severity in children ...

        Research

        A spatio-temporal analysis to identify the drivers of malaria transmission in Bhutan

        Hot spots and clusters of both species were isolated in the central southern part of Bhutan bordering India ...

        Research

        Volatiles or TIVA: Which is the standard of care for pediatric airway procedures? A pro-con discussion

        This pro-con discussion examines both volatiles and TIVA, from the perspective of effectiveness, safety, cost, and environmental impact, ...

        Research

        Gain of chromosome 21 in hematological malignancies: lessons from studying leukemia in children with Down syndrome

        Structural and numerical alterations of chromosome 21 are extremely common in hematological malignancies. While the functional impact of chimeric transcripts from fused chromosome 21 genes such as TEL-AML1, AML1-ETO, or FUS-ERG have been extensively studied, the role of gain of chromosome 21 remains largely unknown. ...

        Research

        AMEND study protocol: A case-control study to assess the long-term impact of invasive meningococcal disease in Australian adolescents and young adults

        This study aims to address this evidence gap by assessing the clinical, physical, neurocognitive, economic and societal impact of invasive meningococcal disease ...

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